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Literature DB >> 21882902

Metformin as a geroprotector.

Abstract

Abstract Geroprotectors are drugs that decrease the rate of aging and therefore extend life span. Metformin has been described as a geroprotector, and several studies have shown that metformin can slow down the rate of aging. The mechanisms behind the geroprotective effect of metformin are less established. The goal of this review is to investigate the evidence for the geroprotective effect of metformin and to describe the possible mechanisms behind it.

Entities: Chemical

Mesh：

Substances：
Metformin

Year: 2011 PMID： 21882902 DOI： 10.1089/rej.2011.1153

Source DB: PubMed Journal: Rejuvenation Res ISSN： 1549-1684 Impact factor: 4.663

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Cited

16 in total

Review 1. Role of metformin in treatment of patients with chronic obstructive pulmonary disease: a systematic review.

Authors: Ailing Zhu; Yue Teng; Dehai Ge; Xiujian Zhang; Manman Hu; Xin Yao
Journal: J Thorac Dis Date: 2019-10 Impact factor: 2.895

2. Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism.

Authors: Adam Ertel; Aristotelis Tsirigos; Diana Whitaker-Menezes; Ruth C Birbe; Stephanos Pavlides; Ubaldo E Martinez-Outschoorn; Richard G Pestell; Anthony Howell; Federica Sotgia; Michael P Lisanti
Journal: Cell Cycle Date: 2012-01-15 Impact factor: 4.534

Review 3. Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease.

Authors: Urmila Maitra; Lukasz Ciesla
Journal: Medchemcomm Date: 2019-04-30 Impact factor: 3.597

Review 4. Metformin: A Hopeful Promise in Aging Research.

Authors: Marta G Novelle; Ahmed Ali; Carlos Diéguez; Michel Bernier; Rafael de Cabo
Journal: Cold Spring Harb Perspect Med Date: 2016-03-01 Impact factor: 6.915

Review 5. DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis.

Authors: Zbigniew Darzynkiewicz; Hong Zhao; H Dorota Halicka; Paulina Rybak; Jurek Dobrucki; Donald Wlodkowic
Journal: Crit Rev Clin Lab Sci Date: 2012-11-09 Impact factor: 6.250

Metformin as a geroprotector.

Review 1. Role of metformin in treatment of patients with chronic obstructive pulmonary disease: a systematic review.

2. Is cancer a metabolic rebellion against host aging? In the quest for immortality, tumor cells try to save themselves by boosting mitochondrial metabolism.

Review 3. Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease.

Review 4. Metformin: A Hopeful Promise in Aging Research.

Review 5. DNA damage signaling assessed in individual cells in relation to the cell cycle phase and induction of apoptosis.

6. Age and Periodontal Health - Immunological View.

Review 7. Nutraceutical interventions for promoting healthy aging in invertebrate models.

Review 8. Geroprotectors as a novel therapeutic strategy for COPD, an accelerating aging disease.

9. Potential anti-aging agents suppress the level of constitutive mTOR- and DNA damage- signaling.

Review 10. Metformin in obesity, cancer and aging: addressing controversies.