Literature DB >> 21882331

New insight into marine alkaloid metabolic pathways: revisiting oroidin biosynthesis.

Grégory Genta-Jouve1, Nadja Cachet, Serge Holderith, François Oberhänsli, Jean-Louis Teyssié, Ross Jeffree, Ali Al Mourabit, Olivier P Thomas.   

Abstract

Sponge natural product biosynthesis: A highly sensitive in vivo protocol based on (14)C radiolabeled precursors and beta-imager autoradiography allowed the unraveling of the origin of the pyrrole 2-aminoimidazole-containing key biosynthetic intermediate oroidin. Proline and lysine are now proposed as the early precursors of the pyrrole and the 2-aminoimidazole moieties of oroidin respectively.
Copyright © 2011 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 21882331     DOI： 10.1002/cbic.201100449

Source DB:  PubMed          Journal:  Chembiochem        ISSN： 1439-4227            Impact factor:   3.164


  11 in total

1.  Precursor-Guided Mining of Marine Sponge Metabolomes Lends Insight into Biosynthesis of Pyrrole-Imidazole Alkaloids.

Authors:  Ipsita Mohanty; Samuel G Moore; Dongqi Yi; Jason S Biggs; David A Gaul; Neha Garg; Vinayak Agarwal
Journal:  ACS Chem Biol       Date:  2020-07-29       Impact factor: 5.100

2.  De novo synthesis of benzosceptrin C and nagelamide H from 7-15N-oroidin: implications for pyrrole-aminoimidazole alkaloid biosynthesis.

Authors:  E Paige Stout; Brandon I Morinaka; Yong-Gang Wang; Daniel Romo; Tadeusz F Molinski
Journal:  J Nat Prod       Date:  2012-03-28       Impact factor: 4.050

Review 3.  Dimeric pyrrole-imidazole alkaloids: synthetic approaches and biosynthetic hypotheses.

Authors:  Xiao Wang; Zhiqiang Ma; Xiaolei Wang; Saptarshi De; Yuyong Ma; Chuo Chen
Journal:  Chem Commun (Camb)       Date:  2014-05-15       Impact factor: 6.222

4.  Metabolome consistency: additional parazoanthines from the mediterranean zoanthid parazoanthus axinellae.

Authors:  Coralie Audoin; Vincent Cocandeau; Olivier P Thomas; Adrien Bruschini; Serge Holderith; Grégory Genta-Jouve
Journal:  Metabolites       Date:  2014-05-30

5.  Metabolomic profiling reveals deep chemical divergence between two morphotypes of the zoanthid Parazoanthus axinellae.

Authors:  Nadja Cachet; Grégory Genta-Jouve; Julijana Ivanisevic; Pierre Chevaldonné; Frédéric Sinniger; Gérald Culioli; Thierry Pérez; Olivier P Thomas
Journal:  Sci Rep       Date:  2015-02-06       Impact factor: 4.379

6.  Bromopyrrole Alkaloids with the Inhibitory Effects against the Biofilm Formation of Gram Negative Bacteria.

Authors:  Jingyuan Sun; Jiru Wu; Bang An; Nicole J de Voogd; Wei Cheng; Wenhan Lin
Journal:  Mar Drugs       Date:  2018-01-02       Impact factor: 5.118

7.  Stereochemical Assignment and Absolute Abundance of Nonproteinogenic Amino Acid Homoarginine in Marine Sponges.

Authors:  Ipsita Mohanty; Samuel G Moore; Jason S Biggs; Christopher J Freeman; David A Gaul; Neha Garg; Vinayak Agarwal
Journal:  ACS Omega       Date:  2021-11-25

Review 8.  Secondary metabolites from marine sponges of the genus Agelas: a comprehensive update insight on structural diversity and bioactivity.

Authors:  Mei-Jun Chu; Meng Li; He Ma; Ping-Lin Li; Guo-Qiang Li
Journal:  RSC Adv       Date:  2022-03-09       Impact factor: 3.361

Review 9.  Late-Stage Carbon-14 Labeling and Isotope Exchange: Emerging Opportunities and Future Challenges.

Authors:  Victor Babin; Frédéric Taran; Davide Audisio
Journal:  JACS Au       Date:  2022-06-07

10.  Further insights into brevetoxin metabolism by de novo radiolabeling.

Authors:  Kevin Calabro; Jean-Marie Guigonis; Jean-Louis Teyssié; François Oberhänsli; Jean-Pierre Goudour; Michel Warnau; Marie-Yasmine Dechraoui Bottein; Olivier P Thomas
Journal:  Toxins (Basel)       Date:  2014-06-10       Impact factor: 4.546
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