Kalindi DeSousa1, Mohamed Shaaban Ali. 1. Department of Anaesthesia and ICU, Al Salam International Hospital, 35151, Kuwait, Kuwait. kalindidesousa@gmail.com
Abstract
PURPOSE: Since the introduction of propofol, several drugs and methods have been used to alleviate the pain on its injection. This study was designed to evaluate the effect of adding sevoflurane 3% during preoxygenation in alleviation of pain on propofol injection. METHODS: In this randomized single-blinded study, 100 patients were randomly allocated equally into five groups: sevoflurane-lidocaine-tourniquet (SLT), sevoflurane-lidocaine (SL), lidocaine-tourniquet (LT), lidocaine (L), and sevoflurane (S). Approximately 10 min before the induction of anesthesia, midazolam 1-2 mg was administered intravenously to all patients. All patients received fentanyl 1 µg/kg as pretreatment and a full induction dose of propofol. A blinded anesthesia nurse assessed pain and hand movements throughout the injection of propofol. RESULTS: In the SLT group, all patients (100%) were pain free and had no hand movements. There was no significant difference in pain grade or in hand movements between the L and the S groups, or between the SLT and the SL groups. However, significant differences were observed in pain grade between the SLT and the L groups as well as between the SLT and the S groups. In addition, a significant difference in hand movement was observed only between the SLT and the S groups. CONCLUSION: The addition of 3% sevoflurane at the time of preoxygenation for 1 min along with routine use of lidocaine-tourniquet completely prevented pain upon propofol injection, whereas sevoflurane by itself provided similar analgesia to premixed lidocaine with propofol.
RCT Entities:
PURPOSE: Since the introduction of propofol, several drugs and methods have been used to alleviate the pain on its injection. This study was designed to evaluate the effect of adding sevoflurane 3% during preoxygenation in alleviation of pain on propofol injection. METHODS: In this randomized single-blinded study, 100 patients were randomly allocated equally into five groups: sevoflurane-lidocaine-tourniquet (SLT), sevoflurane-lidocaine (SL), lidocaine-tourniquet (LT), lidocaine (L), and sevoflurane (S). Approximately 10 min before the induction of anesthesia, midazolam 1-2 mg was administered intravenously to all patients. All patients received fentanyl 1 µg/kg as pretreatment and a full induction dose of propofol. A blinded anesthesia nurse assessed pain and hand movements throughout the injection of propofol. RESULTS: In the SLT group, all patients (100%) were pain free and had no hand movements. There was no significant difference in pain grade or in hand movements between the L and the S groups, or between the SLT and the SL groups. However, significant differences were observed in pain grade between the SLT and the L groups as well as between the SLT and the S groups. In addition, a significant difference in hand movement was observed only between the SLT and the S groups. CONCLUSION: The addition of 3% sevoflurane at the time of preoxygenation for 1 min along with routine use of lidocaine-tourniquet completely prevented pain upon propofol injection, whereas sevoflurane by itself provided similar analgesia to premixed lidocaine with propofol.
Authors: A Toscano; C Pancaro; S Giovannoni; G Minelli; C Baldi; G Guerrieri; J A Crowhurst; V A Peduto Journal: Int J Obstet Anesth Date: 2003-04 Impact factor: 2.603
Authors: Y W Huang; H Buerkle; T H Lee; C Y Lu; C R Lin; S H Lin; A K Chou; R Muhammad; L C Yang Journal: Acta Anaesthesiol Scand Date: 2002-09 Impact factor: 2.105