Literature DB >> 21881128

Prolonged selection of pfmdr1 polymorphisms after treatment of falciparum malaria with artemether-lumefantrine in Uganda.

Frederick N Baliraine1, Philip J Rosenthal.   

Abstract

We compared the prevalence of key pfmdr1 alleles between pretreatment Plasmodium falciparum parasite isolates and parasites that emerged after treatment of uncomplicated malaria in a longitudinal cohort of Ugandan children. The pfmdr1 86N, 184F, and 1246D alleles were selected after treatment with artemether-lumefantrine, but not after artesunate-amodiaquine or amodiaquine-sulfadoxine-pyrimethamine. Remarkably, selection persisted in infections presenting up to about 60 days after treatment with artemether-lumefantrine. Thus, parasites selected for decreased drug sensitivity can appear long after predicted exposure to antimalarial drugs. Continued surveillance of the clinical efficacy and in vitro activity of new combination therapies is warranted.

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Year:  2011        PMID： 21881128      PMCID： PMC3164433          DOI： 10.1093/infdis/jir486

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  15 in total

1.  Polymorphisms in the Plasmodium falciparum pfcrt and pfmdr-1 genes and clinical response to chloroquine in Kampala, Uganda.

Authors:  G Dorsey; M R Kamya; A Singh; P J Rosenthal
Journal:  J Infect Dis       Date:  2001-03-27       Impact factor: 5.226

2.  Pgh1 modulates sensitivity and resistance to multiple antimalarials in Plasmodium falciparum.

Authors:  M B Reed; K J Saliba; S R Caruana; K Kirk; A F Cowman
Journal:  Nature       Date:  2000-02-24       Impact factor: 49.962

3.  Chemotherapy, within-host ecology and the fitness of drug-resistant malaria parasites.

Authors:  Silvie Huijben; William A Nelson; Andrew R Wargo; Derek G Sim; Damien R Drew; Andrew F Read
Journal:  Evolution       Date:  2010-08-19       Impact factor: 3.694

4.  The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin.

Authors:  M T Duraisingh; P Jones; I Sambou; L von Seidlein; M Pinder; D C Warhurst
Journal:  Mol Biochem Parasitol       Date:  2000-04-30       Impact factor: 1.759

5.  Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparum.

Authors:  M T Duraisingh; C Roper; D Walliker; D C Warhurst
Journal:  Mol Microbiol       Date:  2000-05       Impact factor: 3.501

6.  Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malaria.

Authors:  C T Happi; G O Gbotosho; O A Folarin; A Sowunmi; T Hudson; M O'Neil; W Milhous; D F Wirth; A M J Oduola
Journal:  Antimicrob Agents Chemother       Date:  2008-12-15       Impact factor: 5.191

7.  In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.

Authors:  Leah Mwai; Steven M Kiara; Abdi Abdirahman; Lewa Pole; Anja Rippert; Abdi Diriye; Pete Bull; Kevin Marsh; Steffen Borrmann; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

8.  Pharmacokinetics of artemether-lumefantrine and artesunate-amodiaquine in children in Kampala, Uganda.

Authors:  Julia Mwesigwa; Sunil Parikh; Bryan McGee; Polina German; Troy Drysdale; Joan N Kalyango; Tamara D Clark; Grant Dorsey; Niklas Lindegardh; Anna Annerberg; Philip J Rosenthal; Moses R Kamya; Francesca Aweeka
Journal:  Antimicrob Agents Chemother       Date:  2009-10-19       Impact factor: 5.191

9.  In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.

Authors:  Samuel L Nsobya; Moses Kiggundu; Sarah Nanyunja; Moses Joloba; Bryan Greenhouse; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2010-01-11       Impact factor: 5.191

10.  Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.

Authors:  Tamara D Clark; Denise Njama-Meya; Bridget Nzarubara; Catherine Maiteki-Sebuguzi; Bryan Greenhouse; Sarah G Staedke; Moses R Kamya; Grant Dorsey; Philip J Rosenthal
Journal:  PLoS One       Date:  2010-07-30       Impact factor: 3.240
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  42 in total

1.  Intermittent Preventive Treatment with Dihydroartemisinin-Piperaquine in Ugandan Schoolchildren Selects for Plasmodium falciparum Transporter Polymorphisms That Modify Drug Sensitivity.

Authors:  Joaniter I Nankabirwa; Melissa D Conrad; Jennifer Legac; Stephen Tukwasibwe; Patrick Tumwebaze; Bonnie Wandera; Simon J Brooker; Sarah G Staedke; Moses R Kamya; Sam L Nsobya; Grant Dorsey; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2016-09-23       Impact factor: 5.191

2.  Differential prevalence of transporter polymorphisms in symptomatic and asymptomatic falciparum malaria infections in Uganda.

Authors:  Stephen Tukwasibwe; Levi Mugenyi; George W Mbogo; Sheila Nankoberanyi; Catherine Maiteki-Sebuguzi; Moses L Joloba; Samuel L Nsobya; Sarah G Staedke; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2014-01-19       Impact factor: 5.226

3.  Prevalence of Plasmodium falciparum Pfcrt and Pfmdr1 alleles in settings with different levels of Plasmodium vivax co-endemicity in Ethiopia.

Authors:  Elifaged Hailemeskel; Temesgen Menberu; Girma Shumie; Sinknesh Behaksra; Wakweya Chali; Migbaru Keffale; Mulualem Belachew; Getasew Shitaye; Hussien Mohammed; Daniel Abebe; Temesgen Ashine; Chris Drakeley; Hassen Mamo; Beyene Petros; Teun Bousema; Fitsum G Tadesse; Endalamaw Gadisa
Journal:  Int J Parasitol Drugs Drug Resist       Date:  2019-09-09       Impact factor: 4.077

4.  Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children.

Authors:  Melissa D Conrad; Norbert LeClair; Emmanuel Arinaitwe; Humphrey Wanzira; Abel Kakuru; Victor Bigira; Mary Muhindo; Moses R Kamya; Jordan W Tappero; Bryan Greenhouse; Grant Dorsey; Philip J Rosenthal
Journal:  J Infect Dis       Date:  2014-03-08       Impact factor: 5.226

5.  Changing Antimalarial Drug Sensitivities in Uganda.

Authors:  Stephanie A Rasmussen; Frida G Ceja; Melissa D Conrad; Patrick K Tumwebaze; Oswald Byaruhanga; Thomas Katairo; Samuel L Nsobya; Philip J Rosenthal; Roland A Cooper
Journal:  Antimicrob Agents Chemother       Date:  2017-11-22       Impact factor: 5.191

6.  Temporal changes in prevalence of molecular markers mediating antimalarial drug resistance in a high malaria transmission setting in Uganda.

Authors:  George W Mbogo; Sheila Nankoberanyi; Stephen Tukwasibwe; Frederick N Baliraine; Samuel L Nsobya; Melissa D Conrad; Emmanuel Arinaitwe; Moses Kamya; Jordan Tappero; Sarah G Staedke; Grant Dorsey; Bryan Greenhouse; Philip J Rosenthal
Journal:  Am J Trop Med Hyg       Date:  2014-05-05       Impact factor: 2.345

7.  CYP2B6*6 genotype and high efavirenz plasma concentration but not nevirapine are associated with low lumefantrine plasma exposure and poor treatment response in HIV-malaria-coinfected patients.

Authors:  B A Maganda; O M S Minzi; E Ngaimisi; A A R Kamuhabwa; E Aklillu
Journal:  Pharmacogenomics J       Date:  2015-05-12       Impact factor: 3.550

8.  Fitness Consequences of Plasmodium falciparum pfmdr1 Polymorphisms Inferred from Ex Vivo Culture of Ugandan Parasites.

Authors:  Edwin Ochong; Patrick K Tumwebaze; Oswald Byaruhanga; Bryan Greenhouse; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2013-06-24       Impact factor: 5.191

9.  Rapid selection of Plasmodium falciparum chloroquine resistance transporter gene and multidrug resistance gene-1 haplotypes associated with past chloroquine and present artemether-lumefantrine use in Inhambane District, southern Mozambique.

Authors:  Thomas T Thomsen; Laura B Madsen; Helle H Hansson; Elsa V E Tomás; Derek Charlwood; Ib C Bygbjerg; Michael Alifrangis
Journal:  Am J Trop Med Hyg       Date:  2013-02-04       Impact factor: 2.345

10.  Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.

Authors:  Patrick Tumwebaze; Melissa D Conrad; Andrew Walakira; Norbert LeClair; Oswald Byaruhanga; Christine Nakazibwe; Benjamin Kozak; Jessica Bloome; Jaffer Okiring; Abel Kakuru; Victor Bigira; James Kapisi; Jennifer Legac; Jiri Gut; Roland A Cooper; Moses R Kamya; Diane V Havlir; Grant Dorsey; Bryan Greenhouse; Samuel L Nsobya; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2015-03-09       Impact factor: 5.191
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