Literature DB >> 21880488

Pancreatic anticancer activity of a novel geranylgeranylated coumarin derivative.

Tehsina Devji1, Claire Reddy, Christina Woo, Suresh Awale, Shigetoshi Kadota, Dora Carrico-Moniz.   

Abstract

A series of hydroxycoumarin derivatives has been synthesized and evaluated against human pancreatic PANC-1 cancer cells under nutrient-deprived conditions. Several compounds exhibited 100% preferential cytotoxicity at low micromolar concentrations under nutrition starvation, and showed no cytotoxicity under nutrient-rich conditions. In this study, a novel geranylgeranylated ether coumarin derivative 9 was found to exhibit the highest cytotoxic activity of 6.25 μM within 24h. The preferential anti-tumor activity exhibited by compound 9 against PANC-1 under low oxygen and nutrient environment illustrates its great potential as a promising lead structure for the development of novel agents to combat pancreatic cancer.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21880488     DOI： 10.1016/j.bmcl.2011.08.005

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  15 in total

1.  Novel microtubule-targeted agent 6-chloro-4-(methoxyphenyl) coumarin induces G2-M arrest and apoptosis in HeLa cells.

Authors:  Yi-ming Ma; Yu-bo Zhou; Chuan-ming Xie; Dong-mei Chen; Jia Li
Journal:  Acta Pharmacol Sin       Date:  2012-01-23       Impact factor: 6.150

2.  Thiazolidinedione Derivatives: In Silico, In Vitro, In Vivo, Antioxidant and Anti-Diabetic Evaluation.

Authors:  Manal Y Sameeh; Manal M Khowdiary; Hisham S Nassar; Mahmoud M Abdelall; Hamada H Amer; Abdelaaty Hamed; Ahmed A Elhenawy
Journal:  Molecules       Date:  2022-01-27       Impact factor: 4.411

3.  Synthesis and Biological Screening of New 4-Hydroxycoumarin Derivatives and Their Palladium(II) Complexes.

Authors:  Edina H Avdović; Isidora P Petrović; Milena J Stevanović; Luciano Saso; Jasmina M Dimitrić Marković; Nenad D Filipović; Miroslav Ž Živić; Tijana N Cvetić Antić; Milan V Žižić; Nataša V Todorović; Milena Vukić; Srećko R Trifunović; Zoran S Marković
Journal:  Oxid Med Cell Longev       Date:  2021-04-28       Impact factor: 6.543

4.  Discovery Potent of Thiazolidinedione Derivatives as Antioxidant, α-Amylase Inhibitor, and Antidiabetic Agent.

Authors:  Manal Y Sameeh; Manal M Khowdiary; Hisham S Nassar; Mahmoud M Abdelall; Suliman A Alderhami; Ahmed A Elhenawy
Journal:  Biomedicines       Date:  2021-12-23

5.  Coumarin-Palladium(II) Complex Acts as a Potent and Non-Toxic Anticancer Agent against Pancreatic Carcinoma Cells.

Authors:  Aleksandra Krstic; Aleksandar Pavic; Edina Avdovic; Zoran Markovic; Milena Stevanovic; Isidora Petrovic
Journal:  Molecules       Date:  2022-03-25       Impact factor: 4.411

Review 6.  Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications.

Authors:  Manar Ahmed Fouad; Hamida Abdel-Hamid; Mohammed Salah Ayoup
Journal:  RSC Adv       Date:  2020-11-23       Impact factor: 4.036

7.  Identification of the Factors Responsible for the Selective in vitro Cytotoxic Activity of Isoprenylated Coumarin Derivatives under Nutrient-deprived Conditions.

Authors:  Hong Zhang; Ronghao Zhou; Maria Jun; Alyssa F Bacay; Katherine Eyring; Andrew Webb; Dora Carrico-Moniz
Journal:  J Cancer       Date:  2016-01-01       Impact factor: 4.207

8.  Synthesis, inhibition effects and quantum chemical studies of a novel coumarin derivative on the corrosion of mild steel in a hydrochloric acid solution.

Authors:  Khalida F Al-Azawi; Shaimaa B Al-Baghdadi; Ayad Z Mohamed; Ahmed A Al-Amiery; Talib K Abed; Salam A Mohammed; Abdul Amir H Kadhum; Abu Bakar Mohamad
Journal:  Chem Cent J       Date:  2016-04-27       Impact factor: 4.215

9.  Design and Microwave Assisted Synthesis of Coumarin Derivatives as PDE Inhibitors.

Authors:  Mahadev N Kumbar; Ravindra R Kamble; Atulkumar A Kamble; Sujith Raj Salian; Sandhya Kumari; Ramya Nair; Guruprasad Kalthur; Satish Kumar Adiga; D Jagadeesh Prasad
Journal:  Int J Med Chem       Date:  2016-02-21

10.  Design and synthesis of coumarin-based organoselenium as a new hit for myeloprotection and synergistic therapeutic efficacy in adjuvant therapy.

Authors:  Arup Ranjan Patra; Somnath Singha Roy; Abhishek Basu; Avishek Bhuniya; Arin Bhattacharjee; Subhadip Hajra; Ugir Hossain Sk; Rathindranath Baral; Sudin Bhattacharya
Journal:  Sci Rep       Date:  2018-02-01       Impact factor: 4.379
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