Literature DB >> 21879314

Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults.

Daimei Sasayama1, Hiroaki Hori, Toshiya Teraishi, Kotaro Hattori, Miho Ota, Junko Matsuo, Yumiko Kawamoto, Yukiko Kinoshita, Naoji Amano, Hiroshi Kunugi.   

Abstract

Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.

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Year:  2011        PMID： 21879314     DOI： 10.1007/s00702-011-0709-3

Source DB:  PubMed          Journal:  J Neural Transm (Vienna)        ISSN： 0300-9564            Impact factor:   3.575


  23 in total

1.  Reliability and validity of Japanese version of the Mini-International Neuropsychiatric Interview.

Authors:  Tempei Otsubo; Katsutoshi Tanaka; Rumiko Koda; Junko Shinoda; Nana Sano; Satoshi Tanaka; Hiroshi Aoyama; Masaru Mimura; Kunitoshi Kamijima
Journal:  Psychiatry Clin Neurosci       Date:  2005-10       Impact factor: 5.188

2.  Progressive decline in avoidance learning paralleled by inflammatory neurodegeneration in transgenic mice expressing interleukin 6 in the brain.

Authors:  C J Heyser; E Masliah; A Samimi; I L Campbell; L H Gold
Journal:  Proc Natl Acad Sci U S A       Date:  1997-02-18       Impact factor: 11.205

3.  Association of plasma IL-6 and soluble IL-6 receptor levels with the Asp358Ala polymorphism of the IL-6 receptor gene in schizophrenic patients.

Authors:  Daimei Sasayama; Chisato Wakabayashi; Hiroaki Hori; Toshiya Teraishi; Kotaro Hattori; Miho Ota; Masanori Ishikawa; Kunimasa Arima; Teruhiko Higuchi; Naoji Amano; Hiroshi Kunugi
Journal:  J Psychiatr Res       Date:  2011-06-22       Impact factor: 4.791

4.  Interleukin-6 receptor gene polymorphism modulates interleukin-6 levels and the metabolic syndrome: GBCS-CVD.

Authors:  Chao Qiang Jiang; Tai Hing Lam; Bin Liu; Jie Ming Lin; Xiao Jun Yue; Ya Li Jin; Bernard M Y Cheung; G Neil Thomas
Journal:  Obesity (Silver Spring)       Date:  2010-02-25       Impact factor: 5.002

5.  Interleukin-6 covaries inversely with cognitive performance among middle-aged community volunteers.

Authors:  Anna L Marsland; Karen L Petersen; Rama Sathanoori; Matthew F Muldoon; Serina A Neumann; Christopher Ryan; Janine D Flory; Stephen B Manuck
Journal:  Psychosom Med       Date:  2006 Nov-Dec       Impact factor: 4.312

6.  Admixture mapping of an allele affecting interleukin 6 soluble receptor and interleukin 6 levels.

Authors:  David Reich; Nick Patterson; Vijaya Ramesh; Philip L De Jager; Gavin J McDonald; Arti Tandon; Edwin Choy; Donglei Hu; Bani Tamraz; Ludmila Pawlikowska; Christina Wassel-Fyr; Scott Huntsman; Alicja Waliszewska; Elizabeth Rossin; Rongling Li; Melissa Garcia; Alexander Reiner; Robert Ferrell; Steve Cummings; Pui-Yan Kwok; Tamara Harris; Joseph M Zmuda; Elad Ziv
Journal:  Am J Hum Genet       Date:  2007-03-08       Impact factor: 11.025

7.  Cytokines and memory across the mature life span of women.

Authors:  Mats Lekander; Jan von Essen; Marianne Schultzberg; Anna Nixon Andreasson; Anita Garlind; Lars-Olof Hansson; Lars-Göran Nilsson
Journal:  Scand J Psychol       Date:  2011-02-18

8.  Inflammatory markers and cognition in well-functioning African-American and white elders.

Authors:  K Yaffe; K Lindquist; B W Penninx; E M Simonsick; M Pahor; S Kritchevsky; L Launer; L Kuller; S Rubin; T Harris
Journal:  Neurology       Date:  2003-07-08       Impact factor: 9.910

Review 9.  The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10.

Authors:  D V Sheehan; Y Lecrubier; K H Sheehan; P Amorim; J Janavs; E Weiller; T Hergueta; R Baker; G C Dunbar
Journal:  J Clin Psychiatry       Date:  1998       Impact factor: 4.384

10.  The inhibitory effects of interleukin-6 on synaptic plasticity in the rat hippocampus are associated with an inhibition of mitogen-activated protein kinase ERK.

Authors:  V Tancredi; M D'Antuono; C Cafè; S Giovedì; M C Buè; G D'Arcangelo; F Onofri; F Benfenati
Journal:  J Neurochem       Date:  2000-08       Impact factor: 5.372
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  2 in total

1.  Genetic and environmental determinants of population variation in interleukin-6, its soluble receptor and C-reactive protein: insights from identical and fraternal twins.

Authors:  Wellington Z Amaral; Robert F Krueger; Carol D Ryff; Christopher L Coe
Journal:  Brain Behav Immun       Date:  2015-06-15       Impact factor: 7.217

2.  Inflammation, hippocampal volume, and cognition in schizophrenia: results from the Northern Finland Birth Cohort 1966.

Authors:  Brian J Miller; Karl-Heinz Herzig; Jari Jokelainen; Toni Karhu; Sirkka Keinänen-Kiukaanniemi; Marjo-Riitta Järvelin; Juha Veijola; Heimo Viinamäki; Erika Jääskeläinen; Matti Isohanni; Markku Timonen
Journal:  Eur Arch Psychiatry Clin Neurosci       Date:  2020-05-07       Impact factor: 5.270
  2 in total

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