Literature DB >> 21878926

Erroneous analyses of interactions in neuroscience: a problem of significance.

Sander Nieuwenhuis1, Birte U Forstmann, Eric-Jan Wagenmakers.   

Abstract

In theory, a comparison of two experimental effects requires a statistical test on their difference. In practice, this comparison is often based on an incorrect procedure involving two separate tests in which researchers conclude that effects differ when one effect is significant (P < 0.05) but the other is not (P > 0.05). We reviewed 513 behavioral, systems and cognitive neuroscience articles in five top-ranking journals (Science, Nature, Nature Neuroscience, Neuron and The Journal of Neuroscience) and found that 78 used the correct procedure and 79 used the incorrect procedure. An additional analysis suggests that incorrect analyses of interactions are even more common in cellular and molecular neuroscience. We discuss scenarios in which the erroneous procedure is particularly beguiling.

Entities:  

Mesh:

Year:  2011        PMID: 21878926     DOI: 10.1038/nn.2886

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN: 1097-6256            Impact factor:   24.884


  4 in total

1.  What can functional neuroimaging tell the experimental psychologist?

Authors:  Richard Henson
Journal:  Q J Exp Psychol A       Date:  2005-02

2.  Using confidence intervals in within-subject designs.

Authors:  G R Loftus; M E Masson
Journal:  Psychon Bull Rev       Date:  1994-12

3.  Error bars in experimental biology.

Authors:  Geoff Cumming; Fiona Fidler; David L Vaux
Journal:  J Cell Biol       Date:  2007-04-09       Impact factor: 10.539

4.  Guidelines for reporting an fMRI study.

Authors:  Russell A Poldrack; Paul C Fletcher; Richard N Henson; Keith J Worsley; Matthew Brett; Thomas E Nichols
Journal:  Neuroimage       Date:  2007-12-08       Impact factor: 6.556

  4 in total
  237 in total

1.  Age differences in visual statistical learning.

Authors:  Karen L Campbell; Shira Zimerman; M Karl Healey; Michelle M S Lee; Lynn Hasher
Journal:  Psychol Aging       Date:  2012-01-16

2.  Synapse maturation is enhanced in the binocular region of the retinocollicular map prior to eye opening.

Authors:  Moran Furman; Michael C Crair
Journal:  J Neurophysiol       Date:  2012-03-07       Impact factor: 2.714

3.  Drug targets slip-sliding away.

Authors: 
Journal:  Nat Med       Date:  2011-10-11       Impact factor: 53.440

4.  Sleep deprivation and stressors: evidence for elevated negative affect in response to mild stressors when sleep deprived.

Authors:  Jared D Minkel; Siobhan Banks; Oo Htaik; Marisa C Moreta; Christopher W Jones; Eleanor L McGlinchey; Norah S Simpson; David F Dinges
Journal:  Emotion       Date:  2012-02-06

Review 5.  Perils and pitfalls of reporting sex differences.

Authors:  Donna L Maney
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2016-02-01       Impact factor: 6.237

6.  The New Statistics for Better Science: Ask How Much, How Uncertain, and What Else is Known.

Authors:  Robert J Calin-Jageman; Geoff Cumming
Journal:  Am Stat       Date:  2019-03-20       Impact factor: 8.710

7.  Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a gene x environment model.

Authors:  Stal Saurav Shrestha; Daniel S Pine; David A Luckenbaugh; Katarina Varnäs; Ioline D Henter; Robert B Innis; Aleksander A Mathé; Per Svenningsson
Journal:  Neurosci Lett       Date:  2013-11-25       Impact factor: 3.046

8.  Nav1.1-Overexpressing Interneuron Transplants Restore Brain Rhythms and Cognition in a Mouse Model of Alzheimer's Disease.

Authors:  Magdalena Martinez-Losa; Tara E Tracy; Keran Ma; Laure Verret; Alexandra Clemente-Perez; Abdullah S Khan; Inma Cobos; Kaitlyn Ho; Li Gan; Lennart Mucke; Manuel Alvarez-Dolado; Jorge J Palop
Journal:  Neuron       Date:  2018-03-15       Impact factor: 17.173

9.  Associations between autistic traits and fractional anisotropy values in white matter tracts in a nonclinical sample of young adults.

Authors:  Lauren E Bradstreet; Erin E Hecht; Tricia Z King; Jessica L Turner; Diana L Robins
Journal:  Exp Brain Res       Date:  2016-10-03       Impact factor: 1.972

10.  Post-traumatic Reactions and Their Predictors among Workers Who Experienced Serious Violent Acts: Are There Sex Differences?

Authors:  Steve Geoffrion; Jane Goncalves; André Marchand; Richard Boyer; Alain Marchand; Marc Corbière; Stéphane Guay
Journal:  Ann Work Expo Health       Date:  2018-04-18       Impact factor: 2.179

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