Literature DB >> 21878187

Oligonucleotides decoy to NF-kappaB: becoming a reality?

Daniela De Stefano1.   

Abstract

In the last two decades, frontiers in new drug development are represented by genetic code inhibitors. Nuclear factor-kappaB (NF-κB) is a transcription factor playing critical roles in many inflammatory/immune diseases. Decoy oligonucleotides (decoy ONs) epitomize an ideal pharmacological tool to selectively block NF-κB activation. Their use is currently being investigated in several chronic inflammatory-based diseases. However, decoy ONs' clinical use is strongly hampered by several issues. Chemical modifications and/or delivery systems have been investigated to overcome some of these limits. This review describes the successful preclinical and clinical applications of decoy ON against NF-κB in inflammatory-based diseases.

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Year:  2011        PMID： 21878187

Source DB:  PubMed          Journal:  Discov Med        ISSN： 1539-6509            Impact factor:   2.970


  12 in total

Review 1.  NF-κB as a Therapeutic Target in Inflammatory-Associated Bone Diseases.

Authors:  T-H Lin; J Pajarinen; L Lu; A Nabeshima; L A Cordova; Z Yao; S B Goodman
Journal:  Adv Protein Chem Struct Biol       Date:  2016-12-09       Impact factor: 3.507

Review 2.  Involvement of NF-κB/NLRP3 axis in the progression of aseptic loosening of total joint arthroplasties: a review of molecular mechanisms.

Authors:  Mohamad Qoreishi; Meysam Panahi; Omyd Dorodi; Naser Ghanbari; Saman Shakeri Jousheghan
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2022-04-04       Impact factor: 3.000

Review 3.  Dysregulation of the basal RNA polymerase transcription apparatus in cancer.

Authors:  Megan J Bywater; Richard B Pearson; Grant A McArthur; Ross D Hannan
Journal:  Nat Rev Cancer       Date:  2013-05       Impact factor: 60.716

4.  Suppression of NF-κB activity via nanoparticle-based siRNA delivery alters early cartilage responses to injury.

Authors:  Huimin Yan; Xin Duan; Hua Pan; Nilsson Holguin; Muhammad Farooq Rai; Antonina Akk; Luke E Springer; Samuel A Wickline; Linda J Sandell; Christine T N Pham
Journal:  Proc Natl Acad Sci U S A       Date:  2016-09-28       Impact factor: 11.205

Review 5.  NF-κB in colorectal cancer.

Authors:  Aristeidis G Vaiopoulos; Kalliopi Ch Athanasoula; Athanasios G Papavassiliou
Journal:  J Mol Med (Berl)       Date:  2013-05-01       Impact factor: 4.599

Review 6.  Small molecules to the rescue: Inhibition of cytokine signaling in immune-mediated diseases.

Authors:  Massimo Gadina; Nathalia Gazaniga; Laura Vian; Yasuko Furumoto
Journal:  J Autoimmun       Date:  2017-07-01       Impact factor: 7.094

Review 7.  Suppression of chronic inflammation with engineered nanomaterials delivering nuclear factor κB transcription factor decoy oligodeoxynucleotides.

Authors:  Leila Farahmand; Behrad Darvishi; Keivan Majidzadeh-A
Journal:  Drug Deliv       Date:  2017-11       Impact factor: 6.419

8.  Inhibition of Allergic Response by Intranasal Selective NF-κB Decoy Oligodeoxynucleotides in a Murine Model of Allergic Rhinitis.

Authors:  Jee Hye Wee; Yu Lian Zhang; Chae Seo Rhee; Dong Young Kim
Journal:  Allergy Asthma Immunol Res       Date:  2017-01       Impact factor: 5.764

9.  A new approach to transfect NF-κB decoy oligodeoxynucleotides into the periodontal tissue using the ultrasound-microbubble method.

Authors:  Hiroyuki Yamaguchi; Yuji Ishida; Jun Hosomichi; Jun-Ichi Suzuki; Risa Usumi-Fujita; Yasuhiro Shimizu; Sawa Kaneko; Takashi Ono
Journal:  Int J Oral Sci       Date:  2017-04-28       Impact factor: 6.344

10.  Structure and decoy-mediated inhibition of the SOX18/Prox1-DNA interaction.

Authors:  Miriam Klaus; Nina Prokoph; Mathias Girbig; Xuecong Wang; Yong-Heng Huang; Yogesh Srivastava; Linlin Hou; Kamesh Narasimhan; Prasanna R Kolatkar; Mathias Francois; Ralf Jauch
Journal:  Nucleic Acids Res       Date:  2016-03-02       Impact factor: 16.971
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