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Literature DB >> 21877194

Leptin and breast cancer: an overview.

Abstract

Leptin is a well-known mediator of obesity. Leptin and its receptor are overexpressed in breast cancer, especially in high-grade tumors. It has an association with progression and poor survival of breast cancer. Leptin can regulate endothelial cell proliferation and promote angiogenesis. There are several other factors such as insulin and HER2 may be involved in the relationship between leptin and breast cancer. Leptin system has emerged as a new and promising therapeutic target for breast cancer. This review article summarizes the current knowledge about the relation of leptin and breast cancer.

Entities: Disease Gene

Mesh：

Substances：
Biomarkers, Tumor
Leptin

Year: 2011 PMID： 21877194 DOI： 10.1007/s12032-011-0056-0

Source DB: PubMed Journal: Med Oncol ISSN： 1357-0560 Impact factor: 3.064

57 in total

Review 1. Obesity and insulin resistance.

Authors: B B Kahn; J S Flier
Journal: J Clin Invest Date: 2000-08 Impact factor: 14.808

2. Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women.

Authors: M Hollmann; B Runnebaum; I Gerhard
Journal: Int J Obes Relat Metab Disord Date: 1997-06

3. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.

Authors: Laszlo Otvos; Ilona Kovalszky; Mirko Riolfi; Rita Ferla; Julia Olah; Andras Sztodola; Kaushik Nama; Annamaria Molino; Quirino Piubello; John D Wade; Eva Surmacz
Journal: Eur J Cancer Date: 2011-02-23 Impact factor: 9.162

4. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding.

Authors: R Devos; Y Guisez; J Van der Heyden; D W White; M Kalai; M Fountoulakis; G Plaetinck
Journal: J Biol Chem Date: 1997-07-18 Impact factor: 5.157

5. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line.

Authors: Stefania Catalano; Stefania Marsico; Cinzia Giordano; Loredana Mauro; Pietro Rizza; Maria Luisa Panno; Sebastiano Andò
Journal: J Biol Chem Date: 2003-05-06 Impact factor: 5.157

6. Effects of the expression of leptin and leptin receptor (OBR) on the prognosis of early-stage breast cancers.

Authors: Yongnam Kim; Si-Young Kim; Jae Jin Lee; Jeongho Seo; Youn-Wha Kim; Suck Hwan Koh; Hwi-Joong Yoon; Kyung Sam Cho
Journal: Cancer Res Treat Date: 2006-06-30 Impact factor: 4.679

7. Positional cloning of the mouse obese gene and its human homologue.

Authors: Y Zhang; R Proenca; M Maffei; M Barone; L Leopold; J M Friedman
Journal: Nature Date: 1994-12-01 Impact factor: 49.962

8. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro.

Authors: H Y Park; H M Kwon; H J Lim; B K Hong; J Y Lee; B E Park; Y Jang; S Y Cho; H S Kim
Journal: Exp Mol Med Date: 2001-06-30 Impact factor: 8.718

9. Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis.

Authors: Elena Fiorio; Anna Mercanti; Marianna Terrasi; Rocco Micciolo; Andrea Remo; Alessandra Auriemma; Annamaria Molino; Veronica Parolin; Bruno Di Stefano; Franco Bonetti; Antonio Giordano; Gian Luigi Cetto; Eva Surmacz
Journal: BMC Cancer Date: 2008-10-22 Impact factor: 4.430

10. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status.

Authors: Amitabha Ray; Katai J Nkhata; Margot P Cleary
Journal: Int J Oncol Date: 2007-06 Impact factor: 5.650

17 in total

1. Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways.

Authors: Dan Yan; Dimiter Avtanski; Neeraj K Saxena; Dipali Sharma
Journal: J Biol Chem Date: 2012-01-23 Impact factor: 5.157

Review 2. Adipokine leptin in obesity-related pathology of breast cancer.

Authors: Amitabha Ray
Journal: J Biosci Date: 2012-06 Impact factor: 1.826

3. Association between SNPs in Leptin Pathway Genes and Anthropometric, Biochemical, and Dietary Markers Related to Obesity.

Authors: Ricardo Omar Cadena-López; Lourdes Vanessa Hernández-Rodríguez; Adriana Aguilar-Galarza; Willebaldo García-Muñoz; Lorenza Haddad-Talancón; Ma de Lourdes Anzures-Cortes; Claudia Velázquez-Sánchez; Karla Lucero Flores-Viveros; Miriam Aracely Anaya-Loyola; Teresa García-Gasca; Víctor Manuel Rodríguez-García; Ulisses Moreno-Celis
Journal: Genes (Basel) Date: 2022-05-25 Impact factor: 4.141

Leptin and breast cancer: an overview.

Review 1. Obesity and insulin resistance.

2. Impact of waist-hip-ratio and body-mass-index on hormonal and metabolic parameters in young, obese women.

3. Efficacy of a leptin receptor antagonist peptide in a mouse model of triple-negative breast cancer.

4. Ligand-independent dimerization of the extracellular domain of the leptin receptor and determination of the stoichiometry of leptin binding.

5. Leptin enhances, via AP-1, expression of aromatase in the MCF-7 cell line.

6. Effects of the expression of leptin and leptin receptor (OBR) on the prognosis of early-stage breast cancers.

7. Positional cloning of the mouse obese gene and its human homologue.

8. Potential role of leptin in angiogenesis: leptin induces endothelial cell proliferation and expression of matrix metalloproteinases in vivo and in vitro.

9. Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis.

10. Effects of leptin on human breast cancer cell lines in relationship to estrogen receptor and HER2 status.

1. Leptin-induced epithelial-mesenchymal transition in breast cancer cells requires β-catenin activation via Akt/GSK3- and MTA1/Wnt1 protein-dependent pathways.

Review 2. Adipokine leptin in obesity-related pathology of breast cancer.

3. Association between SNPs in Leptin Pathway Genes and Anthropometric, Biochemical, and Dietary Markers Related to Obesity.

4. Engineering tumor constructs to study matrix-dependent angiogenic signaling of breast cancer cells.

5. Effects of different glucose concentrations on the leptin signaling pathway in MCF-7 and T47D breast cancer cells.

6. Effects of leptin on the viability of MCF-7 and T47D cells at different glucose concentrations.

7. Anti-cancer effect of Annona Muricata Linn Leaves Crude Extract (AMCE) on breast cancer cell line.

8. STAT3 activation by leptin receptor is essential for TNBC stem cell maintenance.

9. Leptin and cancer: Pathogenesis and modulation.

10. Resistin and Visfatin Expression in HCT-116 Colorectal Cancer Cell Line.