OBJECTIVE: To detect the frequency and subtypes of HPV in the uterine cervix of HIV-infected women. METHODS: Sample consisted of 288 HIV-infected women, recruited from the public health system of five cities of Minas Gerais, Brazil. Women were seen from August 2003 to August 2008. Cervical samples were collected for cytological analysis and for HPV DNA detection, using polymerase chain reaction (PCR). HPV DNA was classified according to its oncogenic potential in low risk (types 6, 11) and high risk (types 16, 18, 31, 33, 35). Colposcopy was performed, followed by cervical biopsy when necessary. Categorical variables were compared using the Chi-squared test, with a significance level established at the 5% level. RESULTS: HPV prevalence was 78.8%. Most frequent genotypes were HPV-6 (63.9%) and HPV-16 (48.5%). High-risk HPV were observed in 70.5% of the women; low-risk in 71.4%; both high and low-risk HPV were detected in 55.1% of the patients. Multiple HPV genotypes were detected in 64.8% of the patients; two genotypes in 23.8%, and three in 18.9%. CONCLUSION: HPV prevalence was high among HIV-infected women. Multiple HPV genotypes were common in samples from the uterine cervix of HIV-infected women.
OBJECTIVE: To detect the frequency and subtypes of HPV in the uterine cervix of HIV-infectedwomen. METHODS: Sample consisted of 288 HIV-infectedwomen, recruited from the public health system of five cities of Minas Gerais, Brazil. Women were seen from August 2003 to August 2008. Cervical samples were collected for cytological analysis and for HPV DNA detection, using polymerase chain reaction (PCR). HPV DNA was classified according to its oncogenic potential in low risk (types 6, 11) and high risk (types 16, 18, 31, 33, 35). Colposcopy was performed, followed by cervical biopsy when necessary. Categorical variables were compared using the Chi-squared test, with a significance level established at the 5% level. RESULTS: HPV prevalence was 78.8%. Most frequent genotypes were HPV-6 (63.9%) and HPV-16 (48.5%). High-risk HPV were observed in 70.5% of the women; low-risk in 71.4%; both high and low-risk HPV were detected in 55.1% of the patients. Multiple HPV genotypes were detected in 64.8% of the patients; two genotypes in 23.8%, and three in 18.9%. CONCLUSION: HPV prevalence was high among HIV-infectedwomen. Multiple HPV genotypes were common in samples from the uterine cervix of HIV-infectedwomen.
Authors: Jacqueline Cortinhas Monteiro; Ricardo Roberto de Souza Fonseca; Tuane Carolina de Sousa Ferreira; Luana Lorena Silva Rodrigues; Andreza Reis Brasil da Silva; Samara Tatielle Gomes; Rodrigo Vellasco Duarte Silvestre; Andréa Nazaré Monteiro Rangel Silva; Ilze Pamplona; Antonio Carlos Rosário Vallinoto; Ricardo Ishak; Luiz Fernando Almeida Machado Journal: Front Public Health Date: 2021-04-29
Authors: Jessica L Castilho; José Eduardo Levi; Paula M Luz; Mary Catherine Cambou; Tazio Vanni; Angela de Andrade; Mônica Derrico; Valdiléa G Veloso; Beatriz Grinsztejn; Ruth K Friedman Journal: BMC Cancer Date: 2015-06-23 Impact factor: 4.430
Authors: Gisele R de Oliveira; Valdimara C Vieira; Emiliana C Ávila; Fabiana Finger-Jardim; Thaís Dm Caldeira; Fabiane Aa Gatti; Carla V Gonçalves; Sandro G Oliveira; Vanusa P da Hora; Marcelo A Soares; Ana Mb de Martinez Journal: Mem Inst Oswaldo Cruz Date: 2017-07 Impact factor: 2.743