BACKGROUND: Cardiovascular disease in chronic kidney disease (CKD) has peculiar characteristics. The aim of this study was to analyze atherosclerosis, vascular calcification and nitration in arteries from CKD patients. METHODS: External iliac and renal artery segments from 27 stage 5 CKD patients and 25 donor controls, respectively, were collected during the transplantation procedure. RESULTS: CKD patients presented a significantly higher degree of lesion. In a large proportion (72%) of CKD patients, we observed vascular calcifications. Immunohistochemistry for nitrotyrosine revealed a significant increase in nitrotyrosine production in arteries from CKD patients compared with control donors. In addition, within CKD patients, nitrotyrosine staining was significantly stronger in arteries with media calcification when compared with arteries without media calcification. CONCLUSION: The arteriopathy in the CKD patients appears in an early age and seems to be distinct from the arteriopathy of the general population, especially due to intense calcification and vascular oxidative stress.
BACKGROUND:Cardiovascular disease in chronic kidney disease (CKD) has peculiar characteristics. The aim of this study was to analyze atherosclerosis, vascular calcification and nitration in arteries from CKDpatients. METHODS: External iliac and renal artery segments from 27 stage 5 CKDpatients and 25 donor controls, respectively, were collected during the transplantation procedure. RESULTS:CKDpatients presented a significantly higher degree of lesion. In a large proportion (72%) of CKDpatients, we observed vascular calcifications. Immunohistochemistry for nitrotyrosine revealed a significant increase in nitrotyrosine production in arteries from CKDpatients compared with control donors. In addition, within CKDpatients, nitrotyrosine staining was significantly stronger in arteries with media calcification when compared with arteries without media calcification. CONCLUSION: The arteriopathy in the CKDpatients appears in an early age and seems to be distinct from the arteriopathy of the general population, especially due to intense calcification and vascular oxidative stress.
Authors: Ruslan Rafikov; Christiana Dimitropoulou; Saurabh Aggarwal; Archana Kangath; Christine Gross; Daniel Pardo; Shruti Sharma; Agnieszka Jezierska-Drutel; Vijay Patel; Connie Snead; Rudolf Lucas; Alexander Verin; David Fulton; John D Catravas; Stephen M Black Journal: J Biol Chem Date: 2014-01-07 Impact factor: 5.157
Authors: Lixia Zeng; Anna V Mathew; Jaeman Byun; Kevin B Atkins; Frank C Brosius; Subramaniam Pennathur Journal: J Biol Chem Date: 2018-03-26 Impact factor: 5.157
Authors: Ahmed Bakillah; Fasika Tedla; Isabelle Ayoub; Devon John; Allen J Norin; M Mahmood Hussain; Clinton Brown Journal: Mediators Inflamm Date: 2015-11-15 Impact factor: 4.711
Authors: Rayana A P Maciel; Regiane S Cunha; Valentina Busato; Célia R C Franco; Paulo C Gregório; Carla J R Dolenga; Lia S Nakao; Ziad A Massy; Agnès Boullier; Roberto Pecoits-Filho; Andréa E M Stinghen Journal: Toxins (Basel) Date: 2018-10-07 Impact factor: 4.546
Authors: Ligia Maria Claro; Andrea N Moreno-Amaral; Ana Carolina Gadotti; Carla J Dolenga; Lia S Nakao; Marina L V Azevedo; Lucia de Noronha; Marcia Olandoski; Thyago P de Moraes; Andréa E M Stinghen; Roberto Pécoits-Filho Journal: Toxins (Basel) Date: 2018-09-23 Impact factor: 4.546