Literature DB >> 2187625

The effect of DNA replication on mutation of the Saccharomyces cerevisiae CDC8 gene.

D Zaborowska1, J Zuk.   

Abstract

Incubation in YPD medium under permissive conditions when DNA replication is going on, strongly stimulates the induction of cdc+ colonies of UV-irradiated cells of yeast strains HB23 (cdc8-1/cdc8-3), HB26 (cdc8-3/cdc8-3) and HB7 (cdc8-1/cdc8-1). Inhibition of DNA replication by hydroxyurea, araCMP, cycloheximide or caffeine or else by incubation in phosphate buffer pH 7.0, abolishes this stimulation. Thus the replication of DNA is strongly correlated with the high induction of cdc+ colonies by UV irradiation. It is postulated that these UV-induced cdc+ colonies arise as the result infidelity in DNA replication.

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Year:  1990        PMID： 2187625     DOI： 10.1007/bf00314872

Source DB:  PubMed          Journal:  Curr Genet        ISSN： 0172-8083            Impact factor:   3.886


  13 in total

Review 1.  Mutagenesis and deoxyribonucleotide pool imbalance.

Authors:  B A Kunz
Journal:  Mutat Res       Date:  1988 Jul-Aug       Impact factor: 2.433

2.  Replication of the nuclear genome in yeast does not require concomitant protein synthesis.

Authors:  D H Williamson
Journal:  Biochem Biophys Res Commun       Date:  1973-06-08       Impact factor: 3.575

3.  Genetic control of the cell division cycle in yeast. II. Genes controlling DNA replication and its initiation.

Authors:  L H Hartwell
Journal:  J Mol Biol       Date:  1971-07-14       Impact factor: 5.469

4.  Sequential function of gene products relative to DNA synthesis in the yeast cell cycle.

Authors:  L H Hartwell
Journal:  J Mol Biol       Date:  1976-07-15       Impact factor: 5.469

Review 5.  Fidelity of DNA synthesis.

Authors:  L A Loeb; T A Kunkel
Journal:  Annu Rev Biochem       Date:  1982       Impact factor: 23.643

Review 6.  Genetic effects of deoxyribonucleotide pool imbalances.

Authors:  B A Kunz
Journal:  Environ Mutagen       Date:  1982

7.  Transcription of genes encoding enzymes involved in DNA synthesis during the cell cycle of Saccharomyces cerevisiae.

Authors:  E M McIntosh; M H Gadsden; R H Haynes
Journal:  Mol Gen Genet       Date:  1986-09

Review 8.  Caffeine.

Authors:  J Timson
Journal:  Mutat Res       Date:  1977       Impact factor: 2.433

9.  Effect of reversible inhibition of deoxyribonucleic acid synthesis on the yeast cell cycle.

Authors:  M L Slater
Journal:  J Bacteriol       Date:  1973-01       Impact factor: 3.490

10.  Genetic and biochemical consequences of thymidylate stress.

Authors:  B J Barclay; B A Kunz; J G Little; R H Haynes
Journal:  Can J Biochem       Date:  1982-03
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  3 in total

1.  A synthetic lethal screen identifies SLK1, a novel protein kinase homolog implicated in yeast cell morphogenesis and cell growth.

Authors:  C Costigan; S Gehrung; M Snyder
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272

2.  Chemical mutagenesis and DNA synthesis in cdc8, a DNA replication mutant of Saccharomyces cerevisiae.

Authors:  H Baranowska; J Zuk
Journal:  Curr Genet       Date:  1991-12       Impact factor: 3.886

Review 3.  Saccharomyces cerevisiae and Caffeine Implications on the Eukaryotic Cell.

Authors:  Lavinia Liliana Ruta; Ileana Cornelia Farcasanu
Journal:  Nutrients       Date:  2020-08-13       Impact factor: 5.717
  3 in total

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