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Literature DB >> 21876050

Spider venom peptides for gene therapy of Chlamydia infection.

Vassili N Lazarev¹, Nadezhda F Polina, Marina M Shkarupeta, Elena S Kostrjukova, Alexander A Vassilevski, Sergey A Kozlov, Eugene V Grishin, Vadim M Govorun.

Abstract

Spider venoms are vast natural pharmacopoeias selected by evolution. The venom of the ant spider Lachesana tarabaevi contains a wide variety of antimicrobial peptides. We tested six of them (latarcins 1, 2a, 3a, 4b, 5, and cytoinsectotoxin 1a) for their ability to suppress Chlamydia trachomatis infection. HEK293 cells were transfected with plasmid vectors harboring the genes of the selected peptides. Controlled expression of the transgenes led to a significant decrease of C. trachomatis viability inside the infected cells.

Entities: Disease Species

Mesh：

Substances：
Peptides
Spider Venoms

Year: 2011 PMID： 21876050 PMCID： PMC3195042 DOI： 10.1128/AAC.00449-11

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

14 in total

Review 1. Mechanisms of antimicrobial peptide action and resistance.

Authors: Michael R Yeaman; Nannette Y Yount
Journal: Pharmacol Rev Date: 2003-03 Impact factor: 25.468

Review 2. The antibiotic resistome: the nexus of chemical and genetic diversity.

Authors: Gerard D Wright
Journal: Nat Rev Microbiol Date: 2007-03 Impact factor: 60.633

3. A model for antimicrobial gene therapy: demonstration of human beta-defensin 2 antimicrobial activities in vivo.

Authors: George T-J Huang; Hai-Bo Zhang; Daniel Kim; Lide Liu; Tomas Ganz
Journal: Hum Gene Ther Date: 2002-11-20 Impact factor: 5.695

Review 4. Molecular diversity of spider venom.

Authors: A A Vassilevski; S A Kozlov; E V Grishin
Journal: Biochemistry (Mosc) Date: 2009-12 Impact factor: 2.487

Review 5. Therapeutic approaches to Chlamydia infections.

Authors: Laurence Senn; Margaret R Hammerschlag; Gilbert Greub
Journal: Expert Opin Pharmacother Date: 2005-10 Impact factor: 3.889

6. Effect of induced expression of an antimicrobial peptide melittin on Chlamydia trachomatis and Mycoplasma hominis infections in vivo.

Authors: V N Lazarev; M M Shkarupeta; G A Titova; E S Kostrjukova; T A Akopian; V M Govorun
Journal: Biochem Biophys Res Commun Date: 2005-10-17 Impact factor: 3.575

Review 7. Melittin: a membrane-active peptide with diverse functions.

Authors: H Raghuraman; Amitabha Chattopadhyay
Journal: Biosci Rep Date: 2007-10 Impact factor: 3.840

8. Activities of antimicrobial peptides and synergy with enrofloxacin against Mycoplasma pulmonis.

Authors: Lina Fassi Fehri; Henri Wróblewski; Alain Blanchard
Journal: Antimicrob Agents Chemother Date: 2006-11-13 Impact factor: 5.191

9. Induced expression of melittin, an antimicrobial peptide, inhibits infection by Chlamydia trachomatis and Mycoplasma hominis in a HeLa cell line.

Authors: V N Lazarev; T M Parfenova; S K Gularyan; O Yu Misyurina; T A Akopian; V M Govorun
Journal: Int J Antimicrob Agents Date: 2002-02 Impact factor: 5.283

10. Induced expression of the antimicrobial peptide melittin inhibits experimental infection by Mycoplasma gallisepticum in chickens.

Authors: Vassili N Lazarev; Laszlo Stipkovits; Judit Biro; Dora Miklodi; Marina M Shkarupeta; Galina A Titova; Tatiana A Akopian; Vadim M Govorun
Journal: Microbes Infect Date: 2004-05 Impact factor: 2.700

4 in total