Literature DB >> 21875084

Diversity-oriented synthesis of 13- to 18-membered macrolactams via ring-closing metathesis.

Sivaraman Dandapani1, Jason T Lowe, Eamon Comer, Lisa A Marcaurelle.   

Abstract

An efficient build/couple/pair approach to diversity-oriented synthesis was employed to access several structurally complex macrolactams. In this paper, we describe the successful evaluation of ring-closing metathesis toward the systematic generation of skeletal diversity. By appropriately varying the nature and chain length of the alkenol fragment, a diverse collection of 13- to 18-membered macrolactams were obtained.

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Year:  2011        PMID： 21875084      PMCID： PMC4284946          DOI： 10.1021/jo2011957

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


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