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Literature DB >> 21875066

Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.

Omer Kabil¹, Colin L Weeks, Sebastián Carballal, Carmen Gherasim, Beatriz Alvarez, Thomas G Spiro, Ruma Banerjee.

Abstract

Human CBS is a PLP-dependent enzyme that clears homocysteine, gates the flow of sulfur into glutathione, and contributes to the biogenesis of H(2)S. The presence of a heme cofactor in CBS is enigmatic, and its conversion from the ferric- to ferrous-CO state inhibits enzyme activity. The low heme redox potential (-350 mV) has raised questions about the feasibility of the ferrous-CO state forming under physiological conditions. Herein, we provide the first evidence of reversible inhibition of CBS by CO in the presence of a human flavoprotein and NADPH. These data provide a mechanism for cross talk between two gas-signaling systems, CO and H(2)S, via heme-mediated allosteric regulation of CBS.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21875066 PMCID： PMC3183264 DOI： 10.1021/bi201270q

Source DB: PubMed Journal: Biochemistry ISSN： 0006-2960 Impact factor: 3.162

33 in total

1. Cloning and characterization of a novel human dual flavin reductase.

Authors: M J Paine; A P Garner; D Powell; J Sibbald; M Sales; N Pratt; T Smith; D G Tew; C R Wolf
Journal: J Biol Chem Date: 2000-01-14 Impact factor: 5.157

2. Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.

Authors: O Kabil; S Toaka; R LoBrutto; R Shoemaker; R Banerjee
Journal: J Biol Chem Date: 2001-02-26 Impact factor: 5.157

Review 3. Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations.

Authors: Edith Wilson Miles; Jan P Kraus
Journal: J Biol Chem Date: 2004-04-15 Impact factor: 5.157

4. Differential dependence on cysteine from transsulfuration versus transport during T cell activation.

Authors: Sanjay K Garg; Zhonghua Yan; Victor Vitvitsky; Ruma Banerjee
Journal: Antioxid Redox Signal Date: 2010-12-02 Impact factor: 8.401

5. A novel heme protein that acts as a carbon monoxide-dependent transcriptional activator in Rhodospirillum rubrum.

Authors: S Aono; H Nakajima; K Saito; M Okada
Journal: Biochem Biophys Res Commun Date: 1996-11-21 Impact factor: 3.575

6. Redox biochemistry of hydrogen sulfide.

Authors: Omer Kabil; Ruma Banerjee
Journal: J Biol Chem Date: 2010-05-06 Impact factor: 5.157

7. Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation.

Authors: H Olteanu; R Banerjee
Journal: J Biol Chem Date: 2001-07-20 Impact factor: 5.157

8. Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies.

Authors: S Ojha; J Hwang; O Kabil; J E Penner-Hahn; R Banerjee
Journal: Biochemistry Date: 2000-08-29 Impact factor: 3.162

9. Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme.

Authors: Shinichi Taoka; Bryan W Lepore; Omer Kabil; Sunil Ojha; Dagmar Ringe; Ruma Banerjee
Journal: Biochemistry Date: 2002-08-20 Impact factor: 3.162

10. Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase.

Authors: Sebastián Carballal; Peter Madzelan; Carlos F Zinola; Martín Graña; Rafael Radi; Ruma Banerjee; Beatriz Alvarez
Journal: Biochemistry Date: 2008-02-16 Impact factor: 3.162

29 in total

1. Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.

Authors: Aaron T Smith; Yang Su; Daniel J Stevens; Tomas Majtan; Jan P Kraus; Judith N Burstyn
Journal: Biochemistry Date: 2012-07-31 Impact factor: 3.162

2. A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

Authors: Xu Cao; Lei Ding; Zhi-Zhong Xie; Yong Yang; Matthew Whiteman; Philip K Moore; Jin-Song Bian
Journal: Antioxid Redox Signal Date: 2018-06-29 Impact factor: 8.401

Review 3. Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration.

Authors: Nilkantha Sen
Journal: J Mol Biol Date: 2016-12-21 Impact factor: 5.469

Review 4. H2S: A Novel Gasotransmitter that Signals by Sulfhydration.

Authors: Bindu D Paul; Solomon H Snyder
Journal: Trends Biochem Sci Date: 2015-10-01 Impact factor: 13.807

5. Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine β-synthase from Apis mellifera.

Authors: Iker Oyenarte; Tomas Majtan; June Ereño; María Angeles Corral-Rodríguez; Jaroslav Klaudiny; Juraj Majtan; Jan P Kraus; Luis Alfonso Martínez-Cruz
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun Date: 2012-10-30

6. Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.

Authors: Pramod Kumar Yadav; Peter Xie; Ruma Banerjee
Journal: J Biol Chem Date: 2012-09-12 Impact factor: 5.157

Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase.

1. Cloning and characterization of a novel human dual flavin reductase.

2. Pyridoxal phosphate binding sites are similar in human heme-dependent and yeast heme-independent cystathionine beta-synthases. Evidence from 31P NMR and pulsed EPR spectroscopy that heme and PLP cofactors are not proximal in the human enzyme.

Review 3. Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations.

4. Differential dependence on cysteine from transsulfuration versus transport during T cell activation.

5. A novel heme protein that acts as a carbon monoxide-dependent transcriptional activator in Rhodospirillum rubrum.

6. Redox biochemistry of hydrogen sulfide.

7. Human methionine synthase reductase, a soluble P-450 reductase-like dual flavoprotein, is sufficient for NADPH-dependent methionine synthase activation.

8. Characterization of the heme in human cystathionine beta-synthase by X-ray absorption and electron paramagnetic resonance spectroscopies.

9. Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme.

10. Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase.

1. Effect of the disease-causing R266K mutation on the heme and PLP environments of human cystathionine β-synthase.

2. A Review of Hydrogen Sulfide Synthesis, Metabolism, and Measurement: Is Modulation of Hydrogen Sulfide a Novel Therapeutic for Cancer?

Review 3. Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration.

Review 4. H2S: A Novel Gasotransmitter that Signals by Sulfhydration.

5. Purification, crystallization and preliminary crystallographic analysis of the full-length cystathionine β-synthase from Apis mellifera.

6. Allosteric communication between the pyridoxal 5'-phosphate (PLP) and heme sites in the H2S generator human cystathionine β-synthase.

Review 7. Chemical Biology of H₂S Signaling through Persulfidation.

8. Heme-dependent Metabolite Switching Regulates H2S Synthesis in Response to Endoplasmic Reticulum (ER) Stress.

Review 9. Catalytic promiscuity and heme-dependent redox regulation of H₂S synthesis.

Review 10. Enzymology of H2S biogenesis, decay and signaling.

Review 3. Cystathionine beta-synthase: structure, function, regulation, and location of homocystinuria-causing mutations.

Review 3. Functional and Molecular Insights of Hydrogen Sulfide Signaling and Protein Sulfhydration.

Review 4. H2S: A Novel Gasotransmitter that Signals by Sulfhydration.

Review 7. Chemical Biology of H2S Signaling through Persulfidation.

Review 9. Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis.

Review 10. Enzymology of H2S biogenesis, decay and signaling.

Review 7. Chemical Biology of H₂S Signaling through Persulfidation.

Review 9. Catalytic promiscuity and heme-dependent redox regulation of H₂S synthesis.