Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 C(6)-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides.

Literature DB >> 21874540

C(6)-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides.

Jong Min Choi¹, So Jung Chu, Kyong Hoon Ahn, Seok Kyun Kim, Jung Eun Ji, Jong Hoon Won, Hyung Chul Kim, Moon Jung Back, Dae Kyong Kim.

Abstract

Ceramide has been suggested to be not only a tumor-suppressive lipid but also a regulator of phagocytosis. We examined whether exogenous cell-permeable C(6)-ceramide enhances the phagocytic activity of Kupffer cells (KCs) and affects the level of cellular ceramides. Rat KCs were isolated by collagenase digestion and differential centrifugation, using Percoll system. Phagocytic activity was measured by FACS analysis after incubating KCs with fluorescence-conjugated latex beads, and the level of cellular ceramide was analyzed by liquid chromatography tandem-mass spectrometry (LC-MS/MS). In this study we found that permeable C(6)-ceramide increases the cellular levels of endogenous ceramides via a sphingosine-recycling pathway leading to enhanced phagocytosis by KCs.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2011 PMID： 21874540 PMCID： PMC3887646 DOI： 10.1007/s10059-011-1034-2

Source DB: PubMed Journal: Mol Cells ISSN： 1016-8478 Impact factor: 5.034

39 in total

Review 1. The multigenic sphingomyelin synthase family.

Authors: Fikadu Geta Tafesse; Philipp Ternes; Joost C M Holthuis
Journal: J Biol Chem Date: 2006-08-11 Impact factor: 5.157

2. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.

Authors: Iyad Sultan; Can E Senkal; Suriyan Ponnusamy; Jacek Bielawski; Zdzislaw Szulc; Alicja Bielawska; Yusuf A Hannun; Besim Ogretmen
Journal: Biochem J Date: 2006-01-15 Impact factor: 3.857

Review 3. Regulation of ceramide production and apoptosis.

Authors: R N Kolesnick; M Krönke
Journal: Annu Rev Physiol Date: 1998 Impact factor: 19.318

4. Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts.

Authors: Hye Hyun Yoo; Junghyun Son; Dong-Hyun Kim
Journal: J Chromatogr B Analyt Technol Biomed Life Sci Date: 2006-08-07 Impact factor: 3.205

C(6)-ceramide enhances phagocytic activity of Kupffer cells through the production of endogenous ceramides.

Review 1. The multigenic sphingomyelin synthase family.

2. Regulation of the sphingosine-recycling pathway for ceramide generation by oxidative stress, and its role in controlling c-Myc/Max function.

Review 3. Regulation of ceramide production and apoptosis.

4. Liquid chromatography-tandem mass spectrometric determination of ceramides and related lipid species in cellular extracts.

5. Ceramide inhibits IgG-dependent phagocytosis in human polymorphonuclear leukocytes.

6. Induction of endocytic vesicles by exogenous C(6)-ceramide.

Review 7. Metabolism and functions of phosphatidylserine.

8. Ceramide 1-phosphate, a mediator of phagocytosis.

9. The formation of ceramide-1-phosphate during neutrophil phagocytosis and its role in liposome fusion.

10. Sphingomyelinase treatment induces ATP-independent endocytosis.

1. Ceramide-Rubusoside Nanomicelles, a Potential Therapeutic Approach to Target Cancers Carrying p53 Missense Mutations.

2. Salvia-Nelumbinis Naturalis Formula Improved Inflammation in LPS Stressed Macrophages via Upregulating MicroRNA-152.

3. p53 and Ceramide as Collaborators in the Stress Response.