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Literature DB >> 21874468

In vivo measurement of glioma-induced vascular permeability.

Jisook Lee¹, Andrew Baird, Brian P Eliceiri.

Abstract

The normal blood-brain barrier (BBB) consists of tight interendothelial cell junctions and adjacent astrocyte end feet separated by a basal lamina surrounding the endothelium. The interactions between the different cell types of BBB are disrupted in distinct patterns in the microenvironment of glioma. Malignant gliomas infiltrate the surrounding normal brain parenchyma; a process associated with vascular permeability (VP) and breakdown of the BBB. Herein, we describe methods to quantitatively measure glioma-induced vascular permeability, utilizing an orthotopic xenograft model of glioma.

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Year: 2011 PMID： 21874468 PMCID： PMC4251581 DOI： 10.1007/978-1-61779-191-8_28

Source DB: PubMed Journal: Methods Mol Biol ISSN： 1064-3745

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