Literature DB >> 21874179

A novel pathway for maytansinoid release from thioether linked antibody-drug conjugates (ADCs) under oxidative conditions.

Nathan Fishkin1, Erin K Maloney, Ravi V J Chari, Rajeeva Singh.   

Abstract

A novel pathway for ex vivo maytansinoid release from thioether linked antibody maytansinoid conjugates (AMCs) upon incubation in human plasma has been identified. A thioether succinimide-linked AMC can undergo chemical oxidation followed by sulfoxide elimination under mild aqueous conditions (pH 5.5-7.5, 37 °C). Oxidized thioether-linked AMCs exhibit high, target-specific cytotoxicity toward cancer cells. This journal is © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21874179     DOI： 10.1039/c1cc14164c

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  10 in total

Review 1.  Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability.

Authors:  Satish K Singh; Donna L Luisi; Roger H Pak
Journal:  Pharm Res       Date:  2015-05-19       Impact factor: 4.200

Review 2.  Antibody drug conjugates: design and selection of linker, payload and conjugation chemistry.

Authors:  Jessica R McCombs; Shawn C Owen
Journal:  AAPS J       Date:  2015-01-22       Impact factor: 4.009

Review 3.  ADME of antibody-maytansinoid conjugates.

Authors:  Hans K Erickson; John M Lambert
Journal:  AAPS J       Date:  2012-08-09       Impact factor: 4.009

4.  Thiol-blocking electrophiles interfere with labeling and detection of protein sulfenic acids.

Authors:  Julie A Reisz; Erika Bechtold; S Bruce King; Leslie B Poole; Cristina M Furdui
Journal:  FEBS J       Date:  2013-10-16       Impact factor: 5.542

Review 5.  Drug-conjugated antibodies for the treatment of cancer.

Authors:  John M Lambert
Journal:  Br J Clin Pharmacol       Date:  2013-08       Impact factor: 4.335

6.  Site-specific radioiodination of an anti-HER2 single domain antibody fragment with a residualizing prosthetic agent.

Authors:  Yutian Feng; Zhengyuan Zhou; Darryl McDougald; Rebecca L Meshaw; Ganesan Vaidyanathan; Michael R Zalutsky
Journal:  Nucl Med Biol       Date:  2020-05-12       Impact factor: 2.408

7.  Forming next-generation antibody-nanoparticle conjugates through the oriented installation of non-engineered antibody fragments.

Authors:  Michelle K Greene; Daniel A Richards; João C F Nogueira; Katrina Campbell; Peter Smyth; Marcos Fernández; Christopher J Scott; Vijay Chudasama
Journal:  Chem Sci       Date:  2017-08-14       Impact factor: 9.825

8.  Comparison of cRGDfK Peptide Probes with Appended Shielded Heptamethine Cyanine Dye (s775z) for Near Infrared Fluorescence Imaging of Cancer.

Authors:  Rananjaya S Gamage; Dong-Hao Li; Cynthia L Schreiber; Bradley D Smith
Journal:  ACS Omega       Date:  2021-10-30

9.  Gold-catalyzed oxycyclization of allenic carbamates: expeditious synthesis of 1,3-oxazin-2-ones.

Authors:  Benito Alcaide; Pedro Almendros; M Teresa Quirós; Israel Fernández
Journal:  Beilstein J Org Chem       Date:  2013-04-26       Impact factor: 2.883

10.  Fourth World Antibody-Drug Conjugate Summit: February 29-March 1, 2012, Frankfurt, Germany.

Authors:  Alain Beck; John Lambert; Michael Sun; Kedan Lin
Journal:  MAbs       Date:  2012-08-22       Impact factor: 5.857
  10 in total

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