BACKGROUND: 5-Aminolevulinic acid (5-ALA) has already been applied clinically as a photosensitizer. In this study, sonodynamically induced selective antitumour effect of 5-ALA for deep-seated lesions was evaluated. MATERIALS AND METHODS: First, normal rat brains were sonicated via a transducer placed on the dural surface to confirm safe acoustic conditions for normal rat brains. One week after inoculation of brains with C6 rat glioma cells, brains with/without administration of 5-ALA (100 mg/kg body weight) were sonicated. RESULTS: Sonodynamic therapy (SDT) with 5-ALA and focused ultrasound (10 W/cm(2), 1.04 MHz, 5 min) achieved selective antitumour effect against deep-seated experimental glioma. Mean tumour sizes in the largest coronal section in sham-operated rats and rats receiving ultrasound with/without 5-ALA were 29.94±10.39, 18.32±5.69 and 30.81±9.65 mm(2), respectively. Tumour size was significantly smaller in the SDT group than in other groups (p<0.05). CONCLUSION: This experimental rat model showed that SDT appears to be useful in the treatment of deep-seated malignant glioma.
BACKGROUND:5-Aminolevulinic acid (5-ALA) has already been applied clinically as a photosensitizer. In this study, sonodynamically induced selective antitumour effect of 5-ALA for deep-seated lesions was evaluated. MATERIALS AND METHODS: First, normal rat brains were sonicated via a transducer placed on the dural surface to confirm safe acoustic conditions for normal rat brains. One week after inoculation of brains with C6 ratglioma cells, brains with/without administration of 5-ALA (100 mg/kg body weight) were sonicated. RESULTS: Sonodynamic therapy (SDT) with 5-ALA and focused ultrasound (10 W/cm(2), 1.04 MHz, 5 min) achieved selective antitumour effect against deep-seated experimental glioma. Mean tumour sizes in the largest coronal section in sham-operated rats and rats receiving ultrasound with/without 5-ALA were 29.94±10.39, 18.32±5.69 and 30.81±9.65 mm(2), respectively. Tumour size was significantly smaller in the SDT group than in other groups (p<0.05). CONCLUSION: This experimental rat model showed that SDT appears to be useful in the treatment of deep-seated malignant glioma.
Authors: David S Hersh; Anthony J Kim; Jeffrey A Winkles; Howard M Eisenberg; Graeme F Woodworth; Victor Frenkel Journal: Neurosurgery Date: 2016-11 Impact factor: 4.654
Authors: Georgios P Skandalakis; Daniel R Rivera; Caroline D Rizea; Alexandros Bouras; Joe Gerald Jesu Raj; Dominique Bozec; Constantinos G Hadjipanayis Journal: Int J Hyperthermia Date: 2020-07 Impact factor: 3.914
Authors: Luca Raspagliesi; Antonio D'Ammando; Matteo Gionso; Natasha D Sheybani; Maria-Beatriz Lopes; David Moore; Steven Allen; Jeremy Gatesman; Edoardo Porto; Kelsie Timbie; Andrea Franzini; Francesco Di Meco; Jason Sheehan; Zhiyuan Xu; Francesco Prada Journal: Front Oncol Date: 2021-06-21 Impact factor: 6.244