Literature DB >> 2187294

Prenyl proteins in eukaryotic cells: a new type of membrane anchor.

J A Glomset1, M H Gelb, C C Farnsworth.   

Abstract

Recent studies have indicated that eukaryotic cells contain proteins that are post-translationally modified by long-chain, thioether-linked prenyl groups. These proteins include yeast mating factors, ras proteins and nuclear lamins. The modification occurs on a cysteine residue near the C terminus and appears to initiate a set of additional protein modification reactions that promote attachment of the proteins to specific membranes.

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Year:  1990        PMID： 2187294     DOI： 10.1016/0968-0004(90)90213-u

Source DB:  PubMed          Journal:  Trends Biochem Sci        ISSN： 0968-0004            Impact factor:   13.807


  104 in total

1.  Structural analysis of protein prenyl groups and associated C-terminal modifications.

Authors:  M E Whitten; K Yokoyama; D Schieltz; F Ghomashchi; D Lam; J R Yates; K Palczewski; M H Gelb
Journal:  Methods Enzymol       Date:  2000       Impact factor: 1.600

2.  Purification and characterization of an autoregulatory substance capable of regulating the morphological transition in Candida albicans.

Authors:  K B Oh; H Miyazawa; T Naito; H Matsuoka
Journal:  Proc Natl Acad Sci U S A       Date:  2001-03-27       Impact factor: 11.205

3.  Identification and functional expression in yeast of a prenylcysteine alpha-carboxyl methyltransferase gene from Arabidopsis thaliana.

Authors:  D N Crowell; M Kennedy
Journal:  Plant Mol Biol       Date:  2001-03       Impact factor: 4.076

Review 4.  Statins as potential therapeutic agents in multiple sclerosis.

Authors:  Olaf Stüve; Thomas Prod'homme; Sawsan Youssef; Shannon Dunn; Oliver Neuhaus; Martin Weber; Hans-Peter Hartung; Lawrence Steinman; Scott S Zamvil
Journal:  Curr Neurol Neurosci Rep       Date:  2004-05       Impact factor: 5.081

Review 5.  Protein farnesylation and disease.

Authors:  Giuseppe Novelli; Maria Rosaria D'Apice
Journal:  J Inherit Metab Dis       Date:  2012-02-04       Impact factor: 4.982

6.  A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity.

Authors:  K Yokoyama; G W Goodwin; F Ghomashchi; J A Glomset; M H Gelb
Journal:  Proc Natl Acad Sci U S A       Date:  1991-06-15       Impact factor: 11.205

7.  Mutant farnesyltransferase beta subunit of Saccharomyces cerevisiae that can substitute for geranylgeranyltransferase type I beta subunit.

Authors:  H Mitsuzawa; K Esson; F Tamanoi
Journal:  Proc Natl Acad Sci U S A       Date:  1995-02-28       Impact factor: 11.205

8.  Ajoene, a garlic compound, inhibits protein prenylation and arterial smooth muscle cell proliferation.

Authors:  Nicola Ferri; Kohei Yokoyama; Martin Sadilek; Rodolfo Paoletti; Rafael Apitz-Castro; Michael H Gelb; Alberto Corsini
Journal:  Br J Pharmacol       Date:  2003-03       Impact factor: 8.739

9.  Protein geranylgeranyltransferase-I of Trypanosoma cruzi.

Authors:  Kohei Yokoyama; John R Gillespie; Wesley C Van Voorhis; Frederick S Buckner; Michael H Gelb
Journal:  Mol Biochem Parasitol       Date:  2007-10-02       Impact factor: 1.759

Review 10.  Signals on proteins, intracellular targeting and inborn errors of organellar metabolism.

Authors:  J M Tager; J M Aerts; C van den Bogert; R J Wanders
Journal:  J Inherit Metab Dis       Date:  1994       Impact factor: 4.982
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