OBJECTIVE: To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery. METHODS:One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded. RESULTS: The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001). CONCLUSION:Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.
RCT Entities:
OBJECTIVE: To assess the effect of intravenous tranexamic acid on blood loss during and after cesarean delivery. METHODS: One hundred pregnant women were randomized to receive either 10 mg/kg of tranexamic acid or placebo intravenously 20 minutes before incision in a double-blind controlled study. Postplacental delivery blood loss, postoperative hemorrhage 2 hours after surgery, and oxytocin administration were recorded. RESULTS: The patients' mean age, weight, and duration of surgery were similar between the 2 groups. Mean blood loss was significantly less in the tranexamic acid group compared with the control group for both intraoperative bleeding (262.5 ± 39.6 vs 404.7 ± 94.4 mL) and postoperative bleeding (67.1 ± 6.5 vs 141.0 ± 33.9 mL; P<0.001), respectively. Oxytocin administration was significantly less in the tranexamic acid group compared with the control group (39 ± 5.8 vs 43 ± 5.4 units; P=0.001). CONCLUSION: Intravenous tranexamic acid decreased intra- and postoperative blood loss and oxytocin administered in patients delivered by cesarean.
Authors: Lise J Estcourt; Michael Desborough; Susan J Brunskill; Carolyn Doree; Sally Hopewell; Michael F Murphy; Simon J Stanworth Journal: Cochrane Database Syst Rev Date: 2016-03-15
Authors: P Kranke; T Annecke; D H Bremerich; R Hanß; L Kaufner; C Klapp; H Ohnesorge; U Schwemmer; T Standl; S Weber; T Volk Journal: Anaesthesist Date: 2016-01 Impact factor: 1.041