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Literature DB >> 21872346

Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis.

Kathryn M Brennan¹, Francesc Galban-Horcajo, Simon Rinaldi, Colin P O'Leary, Carl S Goodyear, Gabriela Kalna, Ariel Arthur, Christina Elliot, Sue Barnett, Christopher Linington, Jeffrey L Bennett, Gregory P Owens, Hugh J Willison.

Abstract

The presence of oligoclonal bands of IgG (OCB) in cerebrospinal fluid (CSF) is used to establish a diagnosis of multiple sclerosis (MS), but their specificity has remained an enigma since its first description over forty years ago. We now report that the use of lipid arrays identifies heteromeric complexes of myelin derived lipids as a prominent target for this intrathecal B cell response.

Entities: CellLine Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21872346 PMCID： PMC3400538 DOI： 10.1016/j.jneuroim.2011.08.002

Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478

39 in total

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6. Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid protein.

Authors: Gregory P Owens; Andrew J Shearer; Xiaoli Yu; Alanna M Ritchie; Kathryne M Keays; Jeffrey L Bennett; Donald H Gilden; Mark P Burgoon
Journal: J Virol Date: 2006-12 Impact factor: 5.103

7. Antibody-mediated CNS demyelination II. Focal spinal cord lesions induced by implantation of an IgM antisulfatide-secreting hybridoma.

Authors: Jack Rosenbluth; Rolf Schiff; Wei-Lan Liang; Wenkai Dou
Journal: J Neurocytol Date: 2003-03

8. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

Authors: C Linington; M Bradl; H Lassmann; C Brunner; K Vass
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9. Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosis.

Authors: Alanna M Ritchie; Donald H Gilden; R Anthony Williamson; Mark P Burgoon; Xiaoli Yu; Karen Helm; John R Corboy; Gregory P Owens
Journal: J Immunol Date: 2004-07-01 Impact factor: 5.422

10. Antibodies to sulfatide in cerebrospinal fluid of patients with multiple sclerosis.

Authors: Amjad A Ilyas; Zie-Wie Chen; Stuart D Cook
Journal: J Neuroimmunol Date: 2003-06 Impact factor: 3.478

31 in total

Review 1. The utility of cerebrospinal fluid analysis in patients with multiple sclerosis.

Authors: Martin Stangel; Sten Fredrikson; Edgar Meinl; Axel Petzold; Olaf Stüve; Hayrettin Tumani
Journal: Nat Rev Neurol Date: 2013-03-26 Impact factor: 42.937

2. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants.

Authors: Kevin Blauth; John Soltys; Adeline Matschulat; Cory R Reiter; Alanna Ritchie; Nicholas L Baird; Jeffrey L Bennett; Gregory P Owens
Journal: Acta Neuropathol Date: 2015-10-28 Impact factor: 17.088

3. Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins.

Authors: Simone M Brändle; Birgit Obermeier; Makbule Senel; Jessica Bruder; Reinhard Mentele; Mohsen Khademi; Tomas Olsson; Hayrettin Tumani; Wolfgang Kristoferitsch; Friedrich Lottspeich; Hartmut Wekerle; Reinhard Hohlfeld; Klaus Dornmair
Journal: Proc Natl Acad Sci U S A Date: 2016-06-20 Impact factor: 11.205

Lipid arrays identify myelin-derived lipids and lipid complexes as prominent targets for oligoclonal band antibodies in multiple sclerosis.

Review 1. Multiple sclerosis.

Review 2. X-ray crystallography of antibodies.

3. Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination.

4. Restricted use of VH4 germline segments in an acute multiple sclerosis brain.

5. Monoclonal antibodies (O1 to O4) to oligodendrocyte cell surfaces: an immunocytological study in the central nervous system.

6. Screening random peptide libraries with subacute sclerosing panencephalitis brain-derived recombinant antibodies identifies multiple epitopes in the C-terminal region of the measles virus nucleocapsid protein.

7. Antibody-mediated CNS demyelination II. Focal spinal cord lesions induced by implantation of an IgM antisulfatide-secreting hybridoma.

8. Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

9. Comparative analysis of the CD19+ and CD138+ cell antibody repertoires in the cerebrospinal fluid of patients with multiple sclerosis.

10. Antibodies to sulfatide in cerebrospinal fluid of patients with multiple sclerosis.

Review 1. The utility of cerebrospinal fluid analysis in patients with multiple sclerosis.

2. Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid cause demyelination of spinal cord explants.

3. Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins.

Review 4. B Cell-Directed Therapeutics in Multiple Sclerosis: Rationale and Clinical Evidence.

5. Role of toll-like receptors in multiple sclerosis.

Review 6. The role of B cells in the immunopathogenesis of multiple sclerosis.

Review 7. B cells and antibodies in multiple sclerosis pathogenesis and therapy.

8. Protein array-based profiling of CSF identifies RBPJ as an autoantigen in multiple sclerosis.

Review 9. Lipids and lipid-reactive antibodies as biomarkers for multiple sclerosis.

Review 10. The role of immune cells, glia and neurons in white and gray matter pathology in multiple sclerosis.