OBJECTIVE: Hypothermic cardiopulmonary bypass (CPB), although associated with a reduction in oxygen requirement, has a number of disadvantages including detrimental effects on enzymatic function, energy generation, and cellular integrity. Normothermic perfusion is potentially a more physiologic method to maintain the functional integrity of major organ systems. One of the aims of this trial was to compare the effect of normothermic and hypothermic CPB on renal injury in pediatric patients undergoing cardiac surgery. METHODS: Fifty-nine children (median age, 78 months; interquartile range, 39-130) undergoing corrective cardiac surgery were randomized to either hypothermic (28°C) or normothermic (35°C-37°C) CPB. Urinary albumin, retinal binding protein (RBP) and N-acetyl-β-glucosaminidase (NAG) were measured preoperatively, end of CPB, 4, and 24 hours postoperatively and were expressed as a ratio of urinary creatinine. Serum creatinine was measured preoperatively, end of CPB, and 24 and 48 hours postoperatively. Results are expressed as a difference in means (normotheric - hypothermic) or as a ratio of geometric means (normothermic/hypothermic). RESULTS: Baseline characteristics were similar in both groups. For these biochemical markers no significant interactions between treatment and postintervention time were found. Serum creatinine (-2.10; 95% confidence interval [CI], -6.51-2.31), RBP (ratio, 0.96; 95% CI, 0.65-1.41), and NAG (ratio, 0.86; 95% CI, 0.56-1.36) were similar in the 2 groups (P ≥ .34), but the urinary albumin was significantly lower in the normothermic group (ratio, 0.63; 95% CI, 0.42-0.95, P = .03). CONCLUSIONS: Normothermic CPB is associated with similar renal impairment to hypothermic CPB in children undergoing heart surgery.
OBJECTIVE: Hypothermic cardiopulmonary bypass (CPB), although associated with a reduction in oxygen requirement, has a number of disadvantages including detrimental effects on enzymatic function, energy generation, and cellular integrity. Normothermic perfusion is potentially a more physiologic method to maintain the functional integrity of major organ systems. One of the aims of this trial was to compare the effect of normothermic and hypothermic CPB on renal injury in pediatric patients undergoing cardiac surgery. METHODS: Fifty-nine children (median age, 78 months; interquartile range, 39-130) undergoing corrective cardiac surgery were randomized to either hypothermic (28°C) or normothermic (35°C-37°C) CPB. Urinary albumin, retinal binding protein (RBP) and N-acetyl-β-glucosaminidase (NAG) were measured preoperatively, end of CPB, 4, and 24 hours postoperatively and were expressed as a ratio of urinary creatinine. Serum creatinine was measured preoperatively, end of CPB, and 24 and 48 hours postoperatively. Results are expressed as a difference in means (normotheric - hypothermic) or as a ratio of geometric means (normothermic/hypothermic). RESULTS: Baseline characteristics were similar in both groups. For these biochemical markers no significant interactions between treatment and postintervention time were found. Serum creatinine (-2.10; 95% confidence interval [CI], -6.51-2.31), RBP (ratio, 0.96; 95% CI, 0.65-1.41), and NAG (ratio, 0.86; 95% CI, 0.56-1.36) were similar in the 2 groups (P ≥ .34), but the urinary albumin was significantly lower in the normothermic group (ratio, 0.63; 95% CI, 0.42-0.95, P = .03). CONCLUSIONS: Normothermic CPB is associated with similar renal impairment to hypothermic CPB in children undergoing heart surgery.
Authors: Jef Van den Eynde; Nicolas Cloet; Robin Van Lerberghe; Michel Pompeu B O Sá; Dirk Vlasselaers; Jaan Toelen; Jan Y Verbakel; Werner Budts; Marc Gewillig; Shelby Kutty; Hans Pottel; Djalila Mekahli Journal: Clin J Am Soc Nephrol Date: 2021-10 Impact factor: 10.614
Authors: Ahmad Mahir Shamsuddin; Ahmad Mohd Nikman; Saedah Ali; Mohd Rizal Mohd Zain; Abdul Rahim Wong; Antonio Francesco Corno Journal: Front Pediatr Date: 2015-04-28 Impact factor: 3.418
Authors: Sarah Baos; Karen Sheehan; Lucy Culliford; Katie Pike; Lucy Ellis; Andrew J Parry; Serban Stoica; Mohamed T Ghorbel; Massimo Caputo; Chris A Rogers Journal: JMIR Res Protoc Date: 2015-05-25
Authors: Antonio F Corno; Claire Bostock; Simon D Chiles; Joanna Wright; Maria-Teresa Jn Tala; Branko Mimic; Mirjana Cvetkovic Journal: Front Pediatr Date: 2018-08-17 Impact factor: 3.418