BACKGROUND: Recent epidemiologic studies have shown that individuals with periodontitis have a significantly increased risk of metabolic syndrome (MetS). Chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased risk. The aim of present study is to determine whether the presence of periodontitis and MetS is associated with a group or an individual of C-reactive protein (CRP), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α), and homocysteine (HCY) in the serum of a Korean population. METHODS: Medical and periodontal parameters, including CRP, IL-1β, IL-6, IL-8, TNF-α, and HCY, were evaluated in 118 individuals (73 healthy; 20 with periodontitis only; 13 with MetS only; and 12 with both). The community periodontal index was used to assess periodontitis. Age, sex, monthly household income, smoking, and drinking were evaluated as confounders. Analysis of covariance, linear regression analysis, and factor analysis were applied. RESULTS: The group of serologic cytokines was synergistically associated with the periodontitis-MetS coexistence. TNF-α and IL-6 were two representing serologic cytokines in the group. CONCLUSIONS: Our results suggest that a group of systemic biologic markers represented by TNF-α and IL-6 might mediate the association between MetS and periodontitis adjusted for various confounders. Additional evidence is needed to generalize our results more widely.
BACKGROUND: Recent epidemiologic studies have shown that individuals with periodontitis have a significantly increased risk of metabolic syndrome (MetS). Chronic infection and subsequent production of systemic inflammatory markers may be associated with this increased risk. The aim of present study is to determine whether the presence of periodontitis and MetS is associated with a group or an individual of C-reactive protein (CRP), interleukin (IL)-1β, IL-6, IL-8, tumor necrosis factor-α (TNF-α), and homocysteine (HCY) in the serum of a Korean population. METHODS: Medical and periodontal parameters, including CRP, IL-1β, IL-6, IL-8, TNF-α, and HCY, were evaluated in 118 individuals (73 healthy; 20 with periodontitis only; 13 with MetS only; and 12 with both). The community periodontal index was used to assess periodontitis. Age, sex, monthly household income, smoking, and drinking were evaluated as confounders. Analysis of covariance, linear regression analysis, and factor analysis were applied. RESULTS: The group of serologic cytokines was synergistically associated with the periodontitis-MetS coexistence. TNF-α and IL-6 were two representing serologic cytokines in the group. CONCLUSIONS: Our results suggest that a group of systemic biologic markers represented by TNF-α and IL-6 might mediate the association between MetS and periodontitis adjusted for various confounders. Additional evidence is needed to generalize our results more widely.
Authors: Wellington Francisco Rodrigues; Camila Botelho Miguel; Javier Emilio Lazo-Chica; Carlos Antônio Trindade da Silva; Carlos Ueira Vieira; Juliana Trindade Clemente-Napimoga; Carlo José Freire Oliveira; Marcelo Henrique Napimoga Journal: J Indian Soc Periodontol Date: 2019 Nov-Dec