Literature DB >> 21870019

Synthesis of 2,4,6-trisubstituted pyridines via an olefin cross-metathesis/Heck-cyclisation-elimination sequence.

Timothy J Donohoe1, John F Bower, David B Baker, José A Basutto, Louis K M Chan, Peter Gallagher.   

Abstract

Heck reactions were performed on α,β-unsaturated-δ-sulfonamido intermediates, derived from cross metathesis, to allow the instalment of substituents at the β position. Subsequent one-pot cyclisation/elimination provides an operationally simple, catalytic and convergent synthesis of 2,4,6-trisubstituted pyridines. This journal is © The Royal Society of Chemistry 2011

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Year:  2011        PMID: 21870019     DOI: 10.1039/c1cc14257g

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN: 1359-7345            Impact factor:   6.222


  1 in total

1.  De novo synthesis of multisubstituted aryl amines using alkene cross metathesis.

Authors:  Matthew R Tatton; Iain Simpson; Timothy J Donohoe
Journal:  Org Lett       Date:  2014-03-19       Impact factor: 6.005

  1 in total

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