BACKGROUND: Low serum levels of 25-hydroxyvitamin D [25(OH)D] have been associated with a high risk of breast cancer. Since publication of the most current meta-analysis of 25(OH)D and breast cancer risk, two new nested case-control studies have emerged. MATERIALS AND METHODS: A PubMed search for all case-control studies on risk of breast cancer by 25(OH)D concentration identified 11 eligible studies. Data from all 11 studies were combined in order to calculate the pooled odds ratio of the highest vs. lowest quantile of 25(OH)D across all studies. RESULTS: The overall Peto odds ratio summarizing the estimated risk in the highest compared to the lowest quantile across all 11 studies was 0.61 (95% confidence interval 0.47, 0.80). CONCLUSION: This study supports the hypothesis that higher serum 25(OH)D levels reduce the risk of breast cancer. According to the review of observational studies, a serum 25(OH)D level of 47 ng/ml was associated with a 50% lower risk of breast cancer.
BACKGROUND: Low serum levels of 25-hydroxyvitamin D [25(OH)D] have been associated with a high risk of breast cancer. Since publication of the most current meta-analysis of 25(OH)D and breast cancer risk, two new nested case-control studies have emerged. MATERIALS AND METHODS: A PubMed search for all case-control studies on risk of breast cancer by 25(OH)D concentration identified 11 eligible studies. Data from all 11 studies were combined in order to calculate the pooled odds ratio of the highest vs. lowest quantile of 25(OH)D across all studies. RESULTS: The overall Peto odds ratio summarizing the estimated risk in the highest compared to the lowest quantile across all 11 studies was 0.61 (95% confidence interval 0.47, 0.80). CONCLUSION: This study supports the hypothesis that higher serum 25(OH)D levels reduce the risk of breast cancer. According to the review of observational studies, a serum 25(OH)D level of 47 ng/ml was associated with a 50% lower risk of breast cancer.
Authors: Kimmie Ng; Jamil B Scott; Bettina F Drake; Andrew T Chan; Bruce W Hollis; Paulette D Chandler; Gary G Bennett; Edward L Giovannucci; Elizabeth Gonzalez-Suarez; Jeffrey A Meyerhardt; Karen M Emmons; Charles S Fuchs Journal: Am J Clin Nutr Date: 2013-12-24 Impact factor: 7.045
Authors: Cedric F Garland; June Jiwon Kim; Sharif Burgette Mohr; Edward Doerr Gorham; William B Grant; Edward L Giovannucci; Leo Baggerly; Heather Hofflich; Joe Wesley Ramsdell; Kenneth Zeng; Robert P Heaney Journal: Am J Public Health Date: 2014-06-12 Impact factor: 9.308
Authors: Gabriella M Anic; Demetrius Albanes; Sabine Rohrmann; Norma Kanarek; William G Nelson; Gary Bradwin; Nader Rifai; Katherine A McGlynn; Elizabeth A Platz; Alison M Mondul Journal: Clin Endocrinol (Oxf) Date: 2016-04-06 Impact factor: 3.478
Authors: Carole A Baggerly; Raphael E Cuomo; Christine B French; Cedric F Garland; Edward D Gorham; William B Grant; Robert P Heaney; Michael F Holick; Bruce W Hollis; Sharon L McDonnell; Mary Pittaway; Paul Seaton; Carol L Wagner; Alexander Wunsch Journal: J Am Coll Nutr Date: 2015-06-22 Impact factor: 3.169
Authors: Sharif B Mohr; Edward D Gorham; John E Alcaraz; Christopher I Kane; Caroline A Macera; J Kellogg Parsons; Deborah L Wingard; Cedric F Garland Journal: Dermatoendocrinol Date: 2012-04-01