OBJECTIVE: To determine the effect of long term propranolol treatment on body weight. DESIGN: Retrospective analysis of data from a placebo controlled randomised double blind clinical trial (the beta blocker heart attack trial). PATIENTS: 3837 Men and women randomised 5-21 days after an acute myocardial infarction to treatment withplacebo or propranolol for up to 40 months. Patients were followed up at annual visits. MAIN OUTCOME MEASURE: Changes in body weight. RESULTS: At the first annual visit patients treated with propranolol had gained more weight than those given placebo (mean weight gain 2.3 kg v 1.2 kg respectively, mean difference 1.2 kg (95% confidence interval 0.9 to 1.5]. These group differences remained at the second and third annual visits. The difference in weight gain could not be explained by discrepancies in the use of diuretics or in physical activity and was similar in patients of both sexes and of all ages. CONCLUSION: Long term beta blockade results in a sustained weight gain.
RCT Entities:
OBJECTIVE: To determine the effect of long term propranolol treatment on body weight. DESIGN: Retrospective analysis of data from a placebo controlled randomised double blind clinical trial (the beta blocker heart attack trial). PATIENTS: 3837 Men and women randomised 5-21 days after an acute myocardial infarction to treatment with placebo or propranolol for up to 40 months. Patients were followed up at annual visits. MAIN OUTCOME MEASURE: Changes in body weight. RESULTS: At the first annual visit patients treated with propranolol had gained more weight than those given placebo (mean weight gain 2.3 kg v 1.2 kg respectively, mean difference 1.2 kg (95% confidence interval 0.9 to 1.5]. These group differences remained at the second and third annual visits. The difference in weight gain could not be explained by discrepancies in the use of diuretics or in physical activity and was similar in patients of both sexes and of all ages. CONCLUSION: Long term beta blockade results in a sustained weight gain.
Authors: Lee Ingle; Alan S Rigby; Sean Carroll; Ron Butterly; Rod F King; Carlton B Cooke; John Gjf Cleland; Andrew L Clark Journal: Exp Clin Cardiol Date: 2007
Authors: Monica E Lindgren; Christopher P Fagundes; Catherine M Alfano; Stephen P Povoski; Doreen M Agnese; Mark W Arnold; William B Farrar; Lisa D Yee; William E Carson; Carl R Schmidt; Janice K Kiecolt-Glaser Journal: Psychooncology Date: 2012-12-17 Impact factor: 3.894