Literature DB >> 21868222

Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives.

Xue-Liang Shi1, Jian-Feng Ge, Bao-Qiang Liu, Marcel Kaiser, Sergio Wittlin, Reto Brun, Masataka Ihara.   

Abstract

A series of 5-phenyliminobenzo[a]phenoxazine derivatives were synthesized. The in vitro antiprotozoal activities were evaluated against Plasmodium falciparum K1, Trypanosoma cruzi, Leishmania donovani and Trypanosoma brucei rhodesiense. N,N-Diethyl-5-((4-methoxyphenyl)imino)-5H-benzo[a]phenoxazin-9-amine shows IC(50)=0.040 μmol L(-1) with a selective index of 1425 against Plasmodium falciparum K1.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21868222     DOI： 10.1016/j.bmcl.2011.07.112

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis.

Authors:  Lloyd Tanner; Joanna C Evans; Ronnett Seldon; Audrey Jordaan; Digby F Warner; Richard K Haynes; Christopher J Parkinson; Lubbe Wiesner
Journal:  Antimicrob Agents Chemother       Date:  2019-10-22       Impact factor: 5.191

2.  Enhanced antimalarial activity by a novel artemether-lumefantrine lipid emulsion for parenteral administration.

Authors:  Yufan Ma; Tingli Lu; Wen Zhao; Ying Wang; Ting Chen; Qibing Mei; Tao Chen
Journal:  Antimicrob Agents Chemother       Date:  2014-06-30       Impact factor: 5.191

3.  Adsorption to the Surface of Hemozoin Crystals: Structure-Based Design and Synthesis of Amino-Phenoxazine β-Hematin Inhibitors.

Authors:  Tania Olivier; Leigh Loots; Michélle Kok; Marianne de Villiers; Janette Reader; Lyn-Marié Birkholtz; Gareth E Arnott; Katherine A de Villiers
Journal:  ChemMedChem       Date:  2022-04-26       Impact factor: 3.540

Review 4.  Recent advances in malaria drug discovery.

Authors:  Marco A Biamonte; Jutta Wanner; Karine G Le Roch
Journal:  Bioorg Med Chem Lett       Date:  2013-03-27       Impact factor: 2.823

5.  Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage P. falciparum Including PfKI3 C580Y Mutants and Liver Stage P. berghei Parasites.

Authors:  Ho Ning Wong; Vivian Padín-Irizarry; Mariëtte E van der Watt; Janette Reader; Wilna Liebenberg; Lubbe Wiesner; Peter Smith; Korina Eribez; Elizabeth A Winzeler; Dennis E Kyle; Lyn-Marie Birkholtz; Dina Coertzen; Richard K Haynes
Journal:  Front Chem       Date:  2020-01-10       Impact factor: 5.221

6.  Intracellular Accumulation of Novel and Clinically Used TB Drugs Potentiates Intracellular Synergy.

Authors:  Lloyd Tanner; Gabriel T Mashabela; Charles C Omollo; Timothy J de Wet; Christopher J Parkinson; Digby F Warner; Richard K Haynes; Lubbe Wiesner
Journal:  Microbiol Spectr       Date:  2021-09-29
  6 in total

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