Literature DB >> 21867934

An overview of emerging therapies for the treatment of chronic hepatitis C.

Jawad A Ilyas1, John M Vierling.   

Abstract

Chronic hepatitis C (CHC) is a leading cause of chronic hepatitis, cirrhosis, liver failure, and hepatocellular carcinoma (HCC) worldwide. Currently, pegylated interferon (Peg-IFN) and ribavirin therapy achieve curative responses in 40% to 80% of patients, depending on genotype. Recognition of new therapeutic targets for HCV therapy has led to development of novel therapies. The purpose of this review is to summarize the status of novel therapeutics for CHC that promise to increase the safety and efficacy of therapy.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID: 21867934     DOI: 10.1016/j.cld.2011.05.002

Source DB:  PubMed          Journal:  Clin Liver Dis        ISSN: 1089-3261            Impact factor:   6.126


  4 in total

Review 1.  Experimental therapies for yellow fever.

Authors:  Justin G Julander
Journal:  Antiviral Res       Date:  2012-12-10       Impact factor: 5.970

2.  Effect of peginterferon alfa-2a (40KD) on cytochrome P450 isoenzyme activity.

Authors:  Barbara J Brennan; Zhi-Xin Xu; Joseph F Grippo
Journal:  Br J Clin Pharmacol       Date:  2013-02       Impact factor: 4.335

Review 3.  MicroRNAs and hepatitis C virus: toward the end of miR-122 supremacy.

Authors:  Thomas Walter Hoffmann; Gilles Duverlie; Duverlie Gilles; Abderrahmane Bengrine; Bengrine Abderrahmane
Journal:  Virol J       Date:  2012-06-12       Impact factor: 4.099

4.  Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.

Authors:  Ryan C Schoenfeld; David L Bourdet; Ken A Brameld; Elbert Chin; Javier de Vicente; Amy Fung; Seth F Harris; Eun K Lee; Sophie Le Pogam; Vincent Leveque; Jim Li; Alfred S-T Lui; Isabel Najera; Sonal Rajyaguru; Michael Sangi; Sandra Steiner; Francisco X Talamas; Joshua P Taygerly; Junping Zhao
Journal:  J Med Chem       Date:  2013-10-10       Impact factor: 7.446

  4 in total

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