The impact of Haemophilus influenzae serotype B resurgence on the epidemiology of childhood invasive Haemophilus influenzae disease in England and Wales.

This study describes the epidemiology of childhood invasive Haemophilus influenzae disease in England and Wales between 1994 and 2008. H. influenzae serotype b incidence was lowest in 1998 (0.26/100,000), rising to 1.8/100,000 in 2002 before falling to 0.27/100,000 in 2008. During this period, nontype b H. influenzae disease remained stable, but there was a small year-on-year increase (3.4%/y; 95% CI: 1.4-5.5%) in incidence.