BACKGROUND: Nonalcoholic steatohepatitis (NASH) is common in the morbidly obese. It is a condition that can lead to progressive fibrosis and cirrhosis. We determined the prevalence in a population undergoing bariatric surgery and evaluated the possible serologic predictors before the development of fibrosis. METHODS: Liver biopsies were taken from 370 consecutive patients who were undergoing laparoscopic bariatric surgery. The clinical and biochemical parameters were then assessed for correlation with the histologic features of nonalcoholic steatohepatitis. RESULTS: Of the 370 patients, 68 (18%) were found to have NASH. Increased insulin resistance, alanine transaminase, and total bilirubin were independently associated with the presence of NASH. The presence of ≥ 2 of the 3 provided the best combination of sensitivity (.71) and specificity (.71) for predicting NASH. CONCLUSION: Increased insulin resistance, alanine transaminase, and total bilirubin are serologic predictors for the presence of NASH before the development of fibrosis.
BACKGROUND:Nonalcoholic steatohepatitis (NASH) is common in the morbidly obese. It is a condition that can lead to progressive fibrosis and cirrhosis. We determined the prevalence in a population undergoing bariatric surgery and evaluated the possible serologic predictors before the development of fibrosis. METHODS: Liver biopsies were taken from 370 consecutive patients who were undergoing laparoscopic bariatric surgery. The clinical and biochemical parameters were then assessed for correlation with the histologic features of nonalcoholic steatohepatitis. RESULTS: Of the 370 patients, 68 (18%) were found to have NASH. Increased insulin resistance, alanine transaminase, and total bilirubin were independently associated with the presence of NASH. The presence of ≥ 2 of the 3 provided the best combination of sensitivity (.71) and specificity (.71) for predicting NASH. CONCLUSION: Increased insulin resistance, alanine transaminase, and total bilirubin are serologic predictors for the presence of NASH before the development of fibrosis.
Authors: Johanna K DiStefano; Christopher Kingsley; G Craig Wood; Xin Chu; George Argyropoulos; Christopher D Still; Stefania Cotta Doné; Christophe Legendre; Waibhav Tembe; Glenn S Gerhard Journal: Acta Diabetol Date: 2014-09-23 Impact factor: 4.280
Authors: Alexandre Losekann; Antonio C Weston; Angelo A de Mattos; Cristiane V Tovo; Luis A de Carli; Marilia B Espindola; Sergio R Pioner; Gabriela P Coral Journal: Int J Mol Sci Date: 2015-10-23 Impact factor: 5.923
Authors: Setor K Kunutsor; Monika Frysz; Niek Verweij; Lyanne M Kieneker; Stephan J L Bakker; Robin P F Dullaart Journal: Eur J Epidemiol Date: 2019-11-26 Impact factor: 8.082
Authors: Jaromír Petrtýl; Karel Dvořák; Jan Stříteský; Martin Leníček; Alena Jirásková; Václav Šmíd; Martin Haluzík; Radan Brůha; Libor Vítek Journal: Antioxidants (Basel) Date: 2021-12-15