| Literature DB >> 21864611 |
Can Tian1, Yonggang Zhang, Jie Zhang, Yao Deng, Xiaobo Li, Dan Xu, Honglang Huang, Jin Huang, Hong Fan.
Abstract
The +874T/A polymorphism in the interferon-γ (IFN-γ) gene has been extensively examined for association to tuberculosis (TB); however, results of different studies have been inconsistent. The aim of this study was to comprehensively analyze the genetic risk of the +874T/A polymorphism in IFN-γ gene for TB by meta-analysis. A total of 4553 cases and 4631 controls in 21 case-control studies were included in this meta-analysis. The results indicated that the variant T allele carriers had a 27% decreased risk of TB, when compared with the homozygote AA (odds ratio [OR] = 0.73, 95% confidence interval [CI] = 0.61-0.87 for TT + TA versus AA). In the subgroup analysis by ethnicity, significant decreased risks were associated with T allele carriers in Asians (OR= 0.71, 95% CI = 0.52-0.97, p = 0.03) but not in Caucasians (OR = 0.87, 95% CI = 0.65-1.17, p = 0.37). Our results suggest that the IFN-γ +874T/A polymorphism contributes to susceptibility to TB.Entities:
Mesh：
Substances：
Year: 2011 PMID： 21864611 DOI： 10.1016/j.humimm.2011.07.310
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850