Action of dopamine on cyclic AMP-tissue level in the rat pancreas. Interaction with secretin.

Dopamine increased the cyclic AMP content of rat pancreas slices. It only partially displayed the agonist activity of secretin. Haloperidol 10(-4)M, a dopamine blocking agent almost completely inhibited the response to dopamine but had no effect on the response to secretin. Dopamine 10(-3)M, increased the cyclic AMP level induced by a low concentration of secretin and inhibited the production of cyclic AMP observed with a high concentration of secretin. Our data suggest that dopamine in the rat pancreatic tissue does not interfere with the secretin receptor but might act on the same adenylate cyclase.