Literature DB >> 21863050

RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis.

Stanley Lipkowitz1, Allan M Weissman.   

Abstract

The ubiquitin-proteasome system has numerous crucial roles in physiology and pathophysiology. Fundamental to the specificity of this system are ubiquitin-protein ligases (E3s). Of these, the majority are RING finger and RING finger-related E3s. Many RING finger E3s have roles in processes that are central to the maintenance of genomic integrity and cellular homeostasis, such as the anaphase promoting complex/cyclosome (APC/C), the SKP1-cullin 1-F-box protein (SCF) E3s, MDM2, BRCA1, Fanconi anaemia proteins, CBL proteins, von Hippel-Lindau tumour suppressor (VHL) and SIAH proteins. As a result, many RING finger E3s are implicated in either the suppression or the progression of cancer. This Review summarizes current knowledge in this area.

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Year:  2011        PMID： 21863050      PMCID： PMC3542975          DOI： 10.1038/nrc3120

Source DB:  PubMed          Journal:  Nat Rev Cancer        ISSN： 1474-175X            Impact factor:   60.716


  191 in total

1.  Overexpression of the anaphase promoting complex/cyclosome inhibitor Emi1 leads to tetraploidy and genomic instability of p53-deficient cells.

Authors:  Norman L Lehman; Emmy W Verschuren; Jerry Y Hsu; Athena M Cherry; Peter K Jackson
Journal:  Cell Cycle       Date:  2006-07-17       Impact factor: 4.534

2.  Skp2 is oncogenic and overexpressed in human cancers.

Authors:  M Gstaiger; R Jordan; M Lim; C Catzavelos; J Mestan; J Slingerland; W Krek
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-17       Impact factor: 11.205

3.  The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis.

Authors:  P H Maxwell; M S Wiesener; G W Chang; S C Clifford; E C Vaux; M E Cockman; C C Wykoff; C W Pugh; E R Maher; P J Ratcliffe
Journal:  Nature       Date:  1999-05-20       Impact factor: 49.962

4.  Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.

Authors:  P Jaakkola; D R Mole; Y M Tian; M I Wilson; J Gielbert; S J Gaskell; A von Kriegsheim; H F Hebestreit; M Mukherji; C J Schofield; P H Maxwell; C W Pugh; P J Ratcliffe
Journal:  Science       Date:  2001-04-05       Impact factor: 47.728

5.  Amplification of a gene encoding a p53-associated protein in human sarcomas.

Authors:  J D Oliner; K W Kinzler; P S Meltzer; D L George; B Vogelstein
Journal:  Nature       Date:  1992-07-02       Impact factor: 49.962

6.  Mutation of the RAD51C gene in a Fanconi anemia-like disorder.

Authors:  Fiona Vaz; Helmut Hanenberg; Beatrice Schuster; Karen Barker; Constanze Wiek; Verena Erven; Kornelia Neveling; Daniela Endt; Ian Kesterton; Flavia Autore; Franca Fraternali; Marcel Freund; Linda Hartmann; David Grimwade; Roland G Roberts; Heiner Schaal; Shehla Mohammed; Nazneen Rahman; Detlev Schindler; Christopher G Mathew
Journal:  Nat Genet       Date:  2010-04-18       Impact factor: 38.330

7.  Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study.

Authors:  Andrea Eisen; Jan Lubinski; Jan Klijn; Pal Moller; Henry T Lynch; Kenneth Offit; Barbara Weber; Tim Rebbeck; Susan L Neuhausen; Parviz Ghadirian; William D Foulkes; Ruth Gershoni-Baruch; Eitan Friedman; Gadi Rennert; Teresa Wagner; Claudine Isaacs; Charmaine Kim-Sing; Peter Ainsworth; Ping Sun; Steven A Narod
Journal:  J Clin Oncol       Date:  2005-10-20       Impact factor: 44.544

8.  Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53.

Authors:  S N Jones; A E Roe; L A Donehower; A Bradley
Journal:  Nature       Date:  1995-11-09       Impact factor: 49.962

9.  Inhibition of hypoxia-inducible factor is sufficient for growth suppression of VHL-/- tumors.

Authors:  Michael Zimmer; Darrell Doucette; Naila Siddiqui; Othon Iliopoulos
Journal:  Mol Cancer Res       Date:  2004-02       Impact factor: 5.852

10.  Control of chromosome stability by the beta-TrCP-REST-Mad2 axis.

Authors:  Daniele Guardavaccaro; David Frescas; N Valerio Dorrello; Angelo Peschiaroli; Asha S Multani; Timothy Cardozo; Anna Lasorella; Antonio Iavarone; Sandy Chang; Eva Hernando; Michele Pagano
Journal:  Nature       Date:  2008-03-20       Impact factor: 49.962
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  170 in total

Review 1.  HECT and RING finger families of E3 ubiquitin ligases at a glance.

Authors:  Meredith B Metzger; Ventzislava A Hristova; Allan M Weissman
Journal:  J Cell Sci       Date:  2012-02-01       Impact factor: 5.285

2.  Cbl exposes its RING finger.

Authors:  Stephen C Kales; Philip E Ryan; Stanley Lipkowitz
Journal:  Nat Struct Mol Biol       Date:  2012-02-03       Impact factor: 15.369

3.  Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase.

Authors:  Shaoning Jiang; Dae Won Park; Yong Gao; Saranya Ravi; Victor Darley-Usmar; Edward Abraham; Jaroslaw W Zmijewski
Journal:  Cell Signal       Date:  2015-02-26       Impact factor: 4.315

4.  SILAC-Based Quantitative Proteomic Analysis Unveils Arsenite-Induced Perturbation of Multiple Pathways in Human Skin Fibroblast Cells.

Authors:  Fan Zhang; Yongsheng Xiao; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2017-02-14       Impact factor: 3.739

Review 5.  Ubiquitin-dependent sorting in endocytosis.

Authors:  Robert C Piper; Ivan Dikic; Gergely L Lukacs
Journal:  Cold Spring Harb Perspect Biol       Date:  2014-01-01       Impact factor: 10.005

Review 6.  Regulation of cancer stem cells by RING finger ubiquitin ligases.

Authors:  Bin Kang; Xiao-Hong Sun
Journal:  Stem Cell Investig       Date:  2014-02-09

Review 7.  Zinc and zinc-containing biomolecules in childhood brain tumors.

Authors:  Jan Hrabeta; Tomas Eckschlager; Marie Stiborova; Zbynek Heger; Sona Krizkova; Vojtech Adam
Journal:  J Mol Med (Berl)       Date:  2016-09-16       Impact factor: 4.599

Review 8.  Molecular Mechanisms of Arsenic-Induced Disruption of DNA Repair.

Authors:  Lok Ming Tam; Nathan E Price; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2020-02-07       Impact factor: 3.739

9.  Arsenite Targets the RING Finger Domain of Rbx1 E3 Ubiquitin Ligase to Inhibit Proteasome-Mediated Degradation of Nrf2.

Authors:  Ji Jiang; Lok Ming Tam; Pengcheng Wang; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2018-04-23       Impact factor: 3.739

Review 10.  Targeting the ubiquitin pathway for cancer treatment.

Authors:  Jia Liu; Shavali Shaik; Xiangpeng Dai; Qiong Wu; Xiuxia Zhou; Zhiwei Wang; Wenyi Wei
Journal:  Biochim Biophys Acta       Date:  2014-12-04
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