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Literature DB >> 21861102

Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell.

Léa Ziercher¹, Odile Filhol, Béatrice Laudet, Renaud Prudent, Claude Cochet, Thierry Buchou.

Abstract

Programs that govern stem cell maintenance and pluripotency are dependent on extracellular factors and of intrinsic cell modulators. Embryonic stem (ES) cells with a specific depletion of the gene encoding the regulatory subunit of protein kinase CK2 (CK2β) revealed a viability defect. However, analysis of CK2β functions along the neural lineage established CK2β as a positive regulator for neural stem/progenitor cell (NSC) proliferation and multipotency. By using an in vitro genetic conditional approach, we demonstrate in this work that specific domains of CK2β involved in the regulatory function towards CK2 catalytic subunits are crucial structural determinants for ES cell homeostasis.

Entities: Gene

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Year: 2011 PMID： 21861102 DOI： 10.1007/s11010-011-0955-6

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

22 in total

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Authors: Lorenzo A Pinna
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Authors: Emmanuelle Huillard; Léa Ziercher; Olivier Blond; Michael Wong; Jean-Christophe Deloulme; Serhiy Souchelnytskyi; Jacques Baudier; Claude Cochet; Thierry Buchou
Journal: Mol Cell Biol Date: 2010-04-05 Impact factor: 4.272

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Journal: EMBO J Date: 1999-06-01 Impact factor: 11.598

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Journal: Prog Nucleic Acid Res Mol Biol Date: 1998

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Authors: Béatrice Laudet; Caroline Barette; Vincent Dulery; Olivier Renaudet; Pascal Dumy; Alexandra Metz; Renaud Prudent; Alexandre Deshiere; Otto Dideberg; Odile Filhol; Claude Cochet
Journal: Biochem J Date: 2007-12-15 Impact factor: 3.857

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Journal: Exp Cell Res Date: 1991-12 Impact factor: 3.905

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Journal: J Biol Chem Date: 1994-07-08 Impact factor: 5.157

10. Cell biological studies with monoclonal and polyclonal antibodies against human casein kinase II subunit beta demonstrate participation of the kinase in mitogenic signaling.

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Journal: J Biol Chem Date: 1993-02-05 Impact factor: 5.157

3 in total