OBJECTIVE: The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS). METHODS: The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1β, interleukin-6, tumor necrosis factor-alpha (TNF-α), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program. RESULTS: After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05). CONCLUSION: These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.
RCT Entities:
OBJECTIVE: The purpose of this study was to examine the effects of a 6-month therapeutic lifestyle modification (TLM) program on chemokines related to oxidative stress, inflammation, endothelial dysfunction, and arterial stiffness in subjects with metabolic syndrome (MetS). METHODS: The authors performed a randomized controlled trial, assigning 52 women (mean age 62.7 ± 9.0 years) with MetS to a TLM intervention group (n = 31) or a control group (n = 21). The authors provided the TLM intervention group with health screening, exercise, low-calorie diet, and health education and counseling for 6 months and instructed the control group to maintain their usual lifestyle behaviors. Outcome variables included levels of myeloperoxidase (MPO), oxidized low-density lipoprotein (LDL), adiponectin, leptin, resistin, high-sensitivity C-reactive protein (hs-CRP), interleukin-1β, interleukin-6, tumor necrosis factor-alpha (TNF-α), CD40L, monocyte chemotactic protein-1 (MCP-1), retinol-binding protein 4 (RBP-4), endothelin-1, and brachial-ankle pulse wave velocity. The authors used generalized estimating equation (GEE) analyses to estimate the effects of the TLM program. RESULTS: After the 6-month TLM program, hs-CRP levels decreased significantly, and MCP-1 levels increased at a significantly slower rate in the TLM group than they did in the control group (all p < .05). CONCLUSION: These results indicate that a TLM program could be effective for improving patient inflammatory states and may also be effective in preventing cardiovascular complications in subjects with MetS.
Authors: Dong Hoon Lee; Ji Young Kim; Mi Kyung Lee; Choae Lee; Ji-Hee Min; Duck Hyoun Jeong; Ji-Won Lee; Sang Hui Chu; Jeffrey A Meyerhardt; Jennifer Ligibel; Lee W Jones; Nam Kyu Kim; Justin Y Jeon Journal: Support Care Cancer Date: 2013-05-02 Impact factor: 3.603
Authors: Stefan Jordan; Navpreet Tung; Maria Casanova-Acebes; Christie Chang; Claudia Cantoni; Dachuan Zhang; Theresa H Wirtz; Shruti Naik; Samuel A Rose; Chad N Brocker; Anastasiia Gainullina; Daniel Hornburg; Sam Horng; Barbara B Maier; Paolo Cravedi; Derek LeRoith; Frank J Gonzalez; Felix Meissner; Jordi Ochando; Adeeb Rahman; Jerry E Chipuk; Maxim N Artyomov; Paul S Frenette; Laura Piccio; Marie-Luise Berres; Emily J Gallagher; Miriam Merad Journal: Cell Date: 2019-08-22 Impact factor: 41.582
Authors: Anna V Mathew; Lei Li; Jaeman Byun; Yanhong Guo; George Michailidis; Mamta Jaiswal; Y Eugene Chen; Rodica Pop-Busui; Subramaniam Pennathur Journal: Diabetes Care Date: 2018-09-10 Impact factor: 19.112