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Literature DB >> 21858450

Roles for CCN2 in normal physiological processes.

Abstract

CCN2, also known as connective tissue growth factor, is a member of the CCN (CCN1-6) family of modular matricellular proteins. Analysis of CCN2 function in vivo has focused primarily on its key role as a mediator of excess ECM synthesis in multiple fibrotic diseases. However, CCN2 and related family members are widely expressed during development. Recent studies using new genetic models are revealing that CCN2 has essential roles in the development of many tissues. This review focuses on current and emerging data on CCN2 and its functions in chondrogenesis and angiogenesis, and on new studies showing that CCN2 has essential functions during embryonic and postnatal development in a number of epithelial tissues. © Springer Basel AG 2011

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Year: 2011 PMID： 21858450 PMCID： PMC3670951 DOI： 10.1007/s00018-011-0782-7

Source DB: PubMed Journal: Cell Mol Life Sci ISSN： 1420-682X Impact factor: 9.261

71 in total

Review 1. Regulation of PDGF and its receptors in fibrotic diseases.

Authors: James C Bonner
Journal: Cytokine Growth Factor Rev Date: 2004-08 Impact factor: 7.638

2. Immunohistochemical localization of connective tissue growth factor (CTGF) in the mouse embryo between days 7.5 and 14.5 of gestation.

Authors: G A Surveyor; D R Brigstock
Journal: Growth Factors Date: 1999 Impact factor: 2.511

Review 3. The modular architecture of a new family of growth regulators related to connective tissue growth factor.

Authors: P Bork
Journal: FEBS Lett Date: 1993-07-26 Impact factor: 4.124

4. Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.

Authors: P Lindahl; B R Johansson; P Levéen; C Betsholtz
Journal: Science Date: 1997-07-11 Impact factor: 47.728

5. Aberrant Wnt/beta-catenin pathway activation in idiopathic pulmonary fibrosis.

Authors: Marco Chilosi; Venerino Poletti; Alberto Zamò; Maurizio Lestani; Licia Montagna; Paola Piccoli; Serena Pedron; Manuela Bertaso; Aldo Scarpa; Bruno Murer; Alessandra Cancellieri; Roberta Maestro; Gianpietro Semenzato; Claudio Doglioni
Journal: Am J Pathol Date: 2003-05 Impact factor: 4.307

6. The physiological role of CTGF/CCN2 in zebrafish notochond development and biological analysis of the proximal promoter region.

Authors: Ming-Jyun Chiou; Tsung-Tai Chao; Jen-Leih Wu; Ching-Ming Kuo; Jyh-Yih Chen
Journal: Biochem Biophys Res Commun Date: 2006-08-28 Impact factor: 3.575

7. Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor.

Authors: Peter Vorwerk; Bianka Hohmann; Youngman Oh; Ron G Rosenfeld; Ronald M Shymko
Journal: Endocrinology Date: 2002-05 Impact factor: 4.736

8. CTGF inhibits BMP-7 signaling in diabetic nephropathy.

Authors: Tri Q Nguyen; Peggy Roestenberg; Frans A van Nieuwenhoven; Niels Bovenschen; Zeke Li; Leon Xu; Noelynn Oliver; Jan Aten; Jaap A Joles; Cecilia Vial; Enrique Brandan; Karen M Lyons; Roel Goldschmeding
Journal: J Am Soc Nephrol Date: 2008-07-16 Impact factor: 10.121

9. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair.

Authors: A Igarashi; H Okochi; D M Bradham; G R Grotendorst
Journal: Mol Biol Cell Date: 1993-06 Impact factor: 4.138

Review 10. Functions and mechanisms of action of CCN matricellular proteins.

Authors: Chih-Chiun Chen; Lester F Lau
Journal: Int J Biochem Cell Biol Date: 2008-08-15 Impact factor: 5.085

47 in total

1. CCN2 induces cellular senescence in fibroblasts.

Authors: Joon-Ii Jun; Lester F Lau
Journal: J Cell Commun Signal Date: 2016-10-18 Impact factor: 5.782

Review 2. Emerging Roles of Vascular Endothelium in Metabolic Homeostasis.

Authors: Xinchun Pi; Liang Xie; Cam Patterson
Journal: Circ Res Date: 2018-08-03 Impact factor: 17.367

3. CCN proteins: A centralized communication network.

Authors: Bernard Perbal
Journal: J Cell Commun Signal Date: 2013-02-19 Impact factor: 5.782

4. Differential recruitment of co-regulatory proteins to the human estrogen receptor 1 in response to xenoestrogens.

Authors: L Cody Smith; Jessica C Clark; Joseph H Bisesi; P Lee Ferguson; Tara Sabo-Attwood
Journal: Comp Biochem Physiol Part D Genomics Proteomics Date: 2016-04-20 Impact factor: 2.674

5. Emerging roles of CCN proteins in vascular development and pathology.

Authors: Philip A Klenotic; Chao Zhang; Zhiyong Lin
Journal: J Cell Commun Signal Date: 2016-05-30 Impact factor: 5.782

6. The CCN family of proteins: a 25th anniversary picture.

Authors: Annick Perbal; Bernard Perbal
Journal: J Cell Commun Signal Date: 2016-08-31 Impact factor: 5.782

7. Defining the molecular signatures of human right heart failure.

Authors: Jordan L Williams; Omer Cavus; Emefah C Loccoh; Sara Adelman; John C Daugherty; Sakima A Smith; Benjamin Canan; Paul M L Janssen; Sara Koenig; Crystal F Kline; Peter J Mohler; Elisa A Bradley
Journal: Life Sci Date: 2018-01-31 Impact factor: 5.037

8. CTGF regulates cell proliferation, migration, and glucose metabolism through activation of FAK signaling in triple-negative breast cancer.

Authors: Hyungjoo Kim; Seogho Son; Yunhyo Ko; Incheol Shin
Journal: Oncogene Date: 2021-03-10 Impact factor: 9.867

Review 9. Caught between a "Rho" and a hard place: are CCN1/CYR61 and CCN2/CTGF the arbiters of microvascular stiffness?

Authors: Brahim Chaqour
Journal: J Cell Commun Signal Date: 2019-08-02 Impact factor: 5.782

10. Molecular control of vascular development by the matricellular proteins CCN1 (Cyr61) and CCN2 (CTGF).

Authors: Brahim Chaqour
Journal: Trends Dev Biol Date: 2013