BACKGROUND: Urinary tract infections (UTIs) in women are a common problem in primary health care settings. Resistance of bacterial uropathogens to commonly used antibiotics is common in many places. OBJECTIVES: To determine the prevalence of UTI, associated uropathogens and their antimicrobial susceptibility. METHODS: A cross section study carried out at Mulago hospital outpatients' department. Midstream urine samples (MSU) were collected from 399 women, who gave informed consent and fulfilled other study criteria. Quantitative culture method, identification of uropathogens and antibiotic susceptibility testing using the Kirby-Bauer disc diffusion technique were applied to the isolates. RESULTS: Out of 399 MSU samples, 40 pure significant bacterial growths (≥10(5) colony forming units (cfu)/ml of urine) were isolated and these included Escherichia coli, 23 (57.5%), Staphylococcus aureus, 9 (22.5%), Enterococci spp, 6 (15%) and Klebsiella pneumoniae, 2 (5.0%). Overall, sensitivities were: nitrofurantoin (98.3%), cefuroxime (89.3%), and cotrimoxazole (20%) by all uropathogens isolated. CONCLUSIONS: Culture positive UTI among adult non-pregnant women are a common problem, occurring in 10% of the study population. Most bacterial uropathogens showed high sensitivity to nitrofurantoin but low sensitivity to SXT. RECOMMENDATIONS: Nitrofurantoin should be considered as drug of choice for empirical treatment of community acquired uncomplicated UTI in adult non-pregnant women.
BACKGROUND:Urinary tract infections (UTIs) in women are a common problem in primary health care settings. Resistance of bacterial uropathogens to commonly used antibiotics is common in many places. OBJECTIVES: To determine the prevalence of UTI, associated uropathogens and their antimicrobial susceptibility. METHODS: A cross section study carried out at Mulago hospital outpatients' department. Midstream urine samples (MSU) were collected from 399 women, who gave informed consent and fulfilled other study criteria. Quantitative culture method, identification of uropathogens and antibiotic susceptibility testing using the Kirby-Bauer disc diffusion technique were applied to the isolates. RESULTS: Out of 399 MSU samples, 40 pure significant bacterial growths (≥10(5) colony forming units (cfu)/ml of urine) were isolated and these included Escherichia coli, 23 (57.5%), Staphylococcus aureus, 9 (22.5%), Enterococci spp, 6 (15%) and Klebsiella pneumoniae, 2 (5.0%). Overall, sensitivities were: nitrofurantoin (98.3%), cefuroxime (89.3%), and cotrimoxazole (20%) by all uropathogens isolated. CONCLUSIONS: Culture positive UTI among adult non-pregnant women are a common problem, occurring in 10% of the study population. Most bacterial uropathogens showed high sensitivity to nitrofurantoin but low sensitivity to SXT. RECOMMENDATIONS: Nitrofurantoin should be considered as drug of choice for empirical treatment of community acquired uncomplicated UTI in adult non-pregnant women.
Entities:
Keywords:
Bacteriuria; E. coli; Uganda; empiric therapy; urinary tract infections
Authors: Deus Kabugo; Samuel Kizito; Dave Dhara Ashok; Kiwanuka Alexander Graham; Ronald Nabimba; Sandra Namunana; M Richard Kabaka; Beatrice Achan; Florence C Najjuka Journal: Afr Health Sci Date: 2016-12 Impact factor: 0.927
Authors: Martin Odoki; Adamu Almustapha Aliero; Julius Tibyangye; Josephat Nyabayo Maniga; Emmanuel Eilu; Ibrahim Ntulume; Eddie Wampande; Charles Drago Kato; Ezera Agwu; Joel Bazira Journal: Pan Afr Med J Date: 2020-06-02