Literature DB >> 2185752

Endothelin-1 stimulates arachidonate 15-lipoxygenase activity and oxygen radical formation in the rat distal lung.

T Nagase1, Y Fukuchi, C Jo, S Teramoto, Y Uejima, K Ishida, T Shimizu, H Orimo.   

Abstract

We investigated the effects of intravenous bolus of endothelin-1 on the metabolism of eicosanoids and oxygen radicals in the distal lung unit of the rat. Intravenous bolus of endothelin-1 caused a significant increase in 15-hydroxyeicosatetraenoic acid of bronchoalveolar lavage fluid and oxygen radicals produced by the bronchoalveolar cells. Endothelin-1 exhibited a stimulatory effect on the 15-lipoxygenase activity in the lung homogenate. Thus, endothelin-1 may contribute to the inflammatory and hyperreactive process of lungs, by enhancing the release of 15-hydroxyeicosatetraenoic acid and oxygen radicals in the distal lung unit.

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Year:  1990        PMID： 2185752     DOI： 10.1016/0006-291x(90)92347-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  6 in total

1.  Targeting endothelin ETA and ETB receptors inhibits antigen-induced neutrophil migration and mechanical hypernociception in mice.

Authors:  Waldiceu A Verri; Thiago M Cunha; Danilo A Magro; Ana T G Guerrero; Silvio M Vieira; Vanessa Carregaro; Guilherme R Souza; Maria das Graças M O Henriques; Sérgio H Ferreira; Fernando Q Cunha
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-10-15       Impact factor: 3.000

2.  A role for endothelin in bicuculline-induced neurogenic pulmonary oedema in rats.

Authors:  C Herbst; B Tippler; H Shams; T Simmet
Journal:  Br J Pharmacol       Date:  1995-07       Impact factor: 8.739

3.  Oxidative Stress and Microcirculatory Flow Abnormalities in the Ventricles during Atrial Fibrillation.

Authors:  Andreas Goette; Alicja Bukowska; Christopher H Lillig; Uwe Lendeckel
Journal:  Front Physiol       Date:  2012-07-05       Impact factor: 4.566

4.  Acute pro-inflammatory actions of endothelin-1 in the guinea-pig lung: involvement of ETA and ETB receptors.

Authors:  J G Filep; A Fournier; E Földes-Filep
Journal:  Br J Pharmacol       Date:  1995-05       Impact factor: 8.739

5.  Two Years versus One Year of Tianjiu Therapy in Sanfu Days for Chronic Asthma: A Clinical Efficacy Observation Trial.

Authors:  Li Bing Zhu; Wei Zhang; Vivian Wong; Ziea Eric; Kwai Ching Lo; Wai Chung Chan; To Yau; Lei Li
Journal:  Evid Based Complement Alternat Med       Date:  2014-09-11       Impact factor: 2.629

6.  Randomized trial of acupoints herbal patching in Sanfu Days for asthma in clinical remission stage.

Authors:  Libing Zhu; Wei Zhang; Vivian Wong; Ziea Eric; Lixing Lao; Kwaiching Lo; Waichung Chan; To Yau; Lei Li
Journal:  Clin Transl Med       Date:  2016-02-04
  6 in total

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