BACKGROUND: Women living with HIV/AIDS present with a higher prevalence of human papillomavirus (HPV) infection, higher rates of squamous intraepithelial lesions, and are more susceptible to invasive cervical carcinoma progression. OBJECTIVE: We assessed the frequency of precursory cervical lesions of cancer and its risk factors for women living with HIV/AIDS. METHODS: Sociodemographic, clinical, behavioral, and laboratory data were collected from medical records from 2008 to 2009 and analyzed using forward stepwise logistic regression. RESULTS: Medical records of 631 women were reviewed; mean age at AIDS diagnosis was 34 years old (interquartile range = 29-40 years old), 32% were <16 years old at first sexual intercourse; 61% had ≤5 sexual partners during life; 43% had been living with AIDS for ≥9 years; 47% reported previous sexually transmitted infections; 44% presented with HPV infection; and 10% presented with high squamous intraepithelial lesions. Presenting high squamous intraepithelial lesions was significantly associated with home district Human Development Index, age at AIDS diagnosis (>40 years old), time of AIDS diagnosis (>8 years), CD4 cell count <350/mm, and HPV infection. CONCLUSIONS: Frequent squamous intraepithelial neoplasia in these women shows the importance of gynecologic examinations in routine care and follow-up required by those who present with cervical lesions.
BACKGROUND:Women living with HIV/AIDS present with a higher prevalence of humanpapillomavirus (HPV) infection, higher rates of squamous intraepithelial lesions, and are more susceptible to invasive cervical carcinoma progression. OBJECTIVE: We assessed the frequency of precursory cervical lesions of cancer and its risk factors for women living with HIV/AIDS. METHODS: Sociodemographic, clinical, behavioral, and laboratory data were collected from medical records from 2008 to 2009 and analyzed using forward stepwise logistic regression. RESULTS: Medical records of 631 women were reviewed; mean age at AIDS diagnosis was 34 years old (interquartile range = 29-40 years old), 32% were <16 years old at first sexual intercourse; 61% had ≤5 sexual partners during life; 43% had been living with AIDS for ≥9 years; 47% reported previous sexually transmitted infections; 44% presented with HPV infection; and 10% presented with high squamous intraepithelial lesions. Presenting high squamous intraepithelial lesions was significantly associated with home district Human Development Index, age at AIDS diagnosis (>40 years old), time of AIDS diagnosis (>8 years), CD4 cell count <350/mm, and HPV infection. CONCLUSIONS: Frequent squamous intraepithelial neoplasia in these women shows the importance of gynecologic examinations in routine care and follow-up required by those who present with cervical lesions.
Authors: P Mayaud; D K Gill; H A Weiss; E Uledi; L Kopwe; J Todd; G ka-Gina; H Grosskurth; R J Hayes; D C Mabey; C J Lacey Journal: Sex Transm Infect Date: 2001-08 Impact factor: 3.519
Authors: L Stewart Massad; Eric C Seaberg; D Heather Watts; Howard Minkoff; Alexandra M Levine; Donna Henry; Christine Colie; Teresa M Darragh; Nancy A Hessol Journal: Cancer Date: 2009-02-01 Impact factor: 6.860
Authors: Paula Schuman; Suzanne E Ohmit; Robert S Klein; Ann Duerr; Susan Cu-Uvin; Denise J Jamieson; Jean Anderson; Keerti V Shah Journal: J Infect Dis Date: 2003-06-17 Impact factor: 5.226
Authors: Christopher Ng'andwe; John J Lowe; Paula J Richards; Lara Hause; Charles Wood; Peter C Angeletti Journal: BMC Infect Dis Date: 2007-07-16 Impact factor: 3.090