| Literature DB >> 21856453 |
Nikola Lepse1, Wayel H Abdulahad, Cees G M Kallenberg, Peter Heeringa.
Abstract
A group of primary vasculitides is associated with the presence of anti-neutrophil cytoplasmic autoantibodies (ANCA). In these diseases, the contribution of ANCA to disease pathogenesis has been studied extensively. Also, in patients with ANCA-associated vasculitides, the T lymphocyte compartment is dysregulated, as aberrant distribution and function of T cell subsets has been shown. In this review we will discuss the putative role of T lymphocytes in inflammation and granuloma formation, as well as the involvement of B cell compartments in the pathophysiology of ANCA-associated vasculitis.Entities:
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Year: 2011 PMID： 21856453 DOI： 10.1016/j.autrev.2011.08.002
Source DB: PubMed Journal: Autoimmun Rev ISSN： 1568-9972 Impact factor: 9.754