Literature DB >> 2185587

Free radicals and ischemic tissue injury.

S W Werns1, B R Lucchesi.   

Abstract

There is growing evidence that reperfusion of ischemic organs is associated with the formation of free radicals that exacerbate the ischemic injury. Free radicals may damage viable tissue via the peroxidation of lipids and oxidation of protein sulfhydryl groups, leading to perturbations of membrane permeability and enzyme function. Steven Werns and Benedict Lucchesi discuss evidence that activated neutrophils are an important source of free radicals after cardiac and intestinal ischemia, and assess the strategies that have been investigated as ways of alleviating damage caused by free radicals during ischemia-reperfusion.

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Year:  1990        PMID： 2185587     DOI： 10.1016/0165-6147(90)90068-J

Source DB:  PubMed          Journal:  Trends Pharmacol Sci        ISSN： 0165-6147            Impact factor:   14.819


  23 in total

1.  Cardiopulmonary bypass and plasma taurine.

Authors:  K Irita; S Yoshitake; H Okabe; J Shafiq; T F Mohammad; J Yoshitake; S Takahashi
Journal:  J Anesth       Date:  1993-07       Impact factor: 2.078

2.  Effects of doxycycline on intestinal ischemia reperfusion injury induced by abdominal compartment syndrome in a rat model.

Authors:  N Fatih Yaşar; Riza Ozdemir; Enver Ihtiyar; Nilüfer Erkasap; Tülay Köken; Murat Tosun; Setenay Oner; Serdar Erkasap
Journal:  Curr Ther Res Clin Exp       Date:  2010-06

3.  Effect of Lomodex-MgSO(4) in the prevention of reperfusion injury following unilateral testicular torsion: an experimental study in rats.

Authors:  Prashant K Adivarekar; Sarita S Bhagwat; Vijaya Raghavan; A H Bandivdekar
Journal:  Pediatr Surg Int       Date:  2005-02-15       Impact factor: 1.827

4.  Physical and functional sensitivity of zinc finger transcription factors to redox change.

Authors:  X Wu; N H Bishopric; D J Discher; B J Murphy; K A Webster
Journal:  Mol Cell Biol       Date:  1996-03       Impact factor: 4.272

5.  Medical perspective in testicular ischemia-reperfusion injury.

Authors:  Salvatore Arena; Roberta Iacona; Pietro Antonuccio; Tiziana Russo; Vincenzo Salvo; Eloisa Gitto; Pietro Impellizzeri; Carmelo Romeo
Journal:  Exp Ther Med       Date:  2017-03-30       Impact factor: 2.447

6.  MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes.

Authors:  T Minamino; T Yujiri; P J Papst; E D Chan; G L Johnson; N Terada
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

7.  Antibody to CD-18 exerts endothelial and cardiac protective effects in myocardial ischemia and reperfusion.

Authors:  X L Ma; P S Tsao; A M Lefer
Journal:  J Clin Invest       Date:  1991-10       Impact factor: 14.808

8.  Arterial endothelial barrier dysfunction: actions of homocysteine and the hypoxanthine-xanthine oxidase free radical generating system.

Authors:  R S Berman; W Martin
Journal:  Br J Pharmacol       Date:  1993-04       Impact factor: 8.739

9.  Diabetes and mitochondrial oxidative stress: a study using heart mitochondria from the diabetic Goto-Kakizaki rat.

Authors:  Dario Loureiro Santos; Carlos Marques Palmeira; Raquel Seiça; José Dias; José Mesquita; António Joaquim Moreno; Maria Sancha Santos
Journal:  Mol Cell Biochem       Date:  2003-04       Impact factor: 3.396

10.  Role of resident macrophages in canatoxin-induced in vivo neutrophil migration.

Authors:  C Barja-Fidalgo; C R Carlini; J A Guimarães; C A Flores; F Q Cunha; S H Ferreira
Journal:  Inflammation       Date:  1992-02       Impact factor: 4.092
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