BACKGROUND: Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). METHODS: This study included 1532 men and 1856 women, aged 40-70 y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. RESULTS: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p<0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). CONCLUSIONS: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.
BACKGROUND:Leptin and adiponectin are adipokines, shown to have opposing functions for fat metabolism and development of metabolic syndrome. We determined if the ratio of serum leptin to adiponectin (L/A ratio) adjunctively contributes to the risk of metabolic syndrome beyond the homeostasis model assessment of insulin resistance (HOMA-IR). METHODS: This study included 1532 men and 1856 women, aged 40-70 y assessed in the Korean Genomic Rural Cohort Study from 2005 to 2008. The serum concentrations of adiponectin and leptin were measured by radioimmunoassay. Area under the receiver operating characteristic curve (AUROC) analyses were used to describe the ability of L/A ratio and HOMA-IR to differentiate between subjects with and without metabolic syndrome. RESULTS: There were no significant differences in the ability of L/A ratio and HOMA-IR to predict metabolic syndrome (AUROC of L/A ratio vs. HOMA-IR, 0.771 vs. 0.774, p=0.8006 for men; 0.677 vs. 0.691, p=0.3088 for women). There was a significant adjunctive contribution by the L/A ratio, beyond that of HOMA-IR, to the risk of metabolic syndrome in men (p<0.0001 with 0.028 increased AUROC) and women (p=0.025 with 0.017 increased AUROC). CONCLUSIONS: The L/A ratio provides significant adjunctive information to the risk of metabolic syndrome beyond HOMA-IR alone. The L/A ratio could be a good surrogate marker to assess metabolic syndrome.
Authors: A Lasa; J Miranda; M Bulló; R Casas; J Salas-Salvadó; I Larretxi; R Estruch; V Ruiz-Gutiérrez; M P Portillo Journal: Eur J Clin Nutr Date: 2014-02-12 Impact factor: 4.016
Authors: Susana Suárez-García; Josep M Del Bas; Antoni Caimari; Rosa M Escorihuela; Lluís Arola; Manuel Suárez Journal: PLoS One Date: 2017-02-13 Impact factor: 3.240
Authors: Qiaoxuan Wang; Jinhua Yin; Lu Xu; Hong Cheng; Xiaoyuan Zhao; Hongding Xiang; Hugh Simon Lam; Jie Mi; Ming Li Journal: BMC Public Health Date: 2013-03-21 Impact factor: 3.295
Authors: Astrid van Huisstede; Manuel Castro Cabezas; Erwin Birnie; Gert-Jan M van de Geijn; Arjan Rudolphus; Guido Mannaerts; Tjin L Njo; Pieter S Hiemstra; Gert-Jan Braunstahl Journal: J Obes Date: 2013-02-24
Authors: Anna Lubkowska; Aleksandra Radecka; Iwona Bryczkowska; Iwona Rotter; Maria Laszczyńska; Wioleta Dudzińska Journal: Int J Environ Res Public Health Date: 2015-09-14 Impact factor: 3.390