| Literature DB >> 21855347 |
Caroline C Friedel1, Jürgen Haas.
Abstract
Novel high-throughput technologies such as yeast two-hybrid and RNA interference (RNAi) screens provide the tools to study interactions between viral proteins and the host on a genomic scale. In this review, we provide an overview of studies in which these technologies were applied and of computational approaches for the analysis of the identified viral interactors in the context of the host cell. The results of these studies illustrate the advantages of integrative systems biology approaches in the investigation of viral pathogens.Mesh:
Substances:
Year: 2011 PMID: 21855347 DOI: 10.1016/j.tim.2011.07.003
Source DB: PubMed Journal: Trends Microbiol ISSN: 0966-842X Impact factor: 17.079