Literature DB >> 2185333

Neutrophil-activating properties of the melanoma growth-stimulatory activity.

B Moser1, I Clark-Lewis, R Zwahlen, M Baggiolini.   

Abstract

Melanoma growth-stimulatory activity (MGSA), a peptide reported to be mitogenic for Hs294T human melanoma cells, has extensive sequence similarity to the neutrophil-activating peptide NAP-1/IL-8, suggesting functional similarities. To test this hypothesis, MGSA was chemically synthesized and tested for its effects on human neutrophils. It was found to induce chemotaxis, exocytosis of elastase, and changes in cytosolic-free calcium to an extent and at concentrations similar to NAP-1/IL-8. However, MGSA was considerably less potent than NAP-1/IL-8 in inducing the respiratory burst. Intradermal injections in rats of MGSA resulted in a massive accumulation of neutrophils. Our data demonstrate that, apart from its growth-stimulatory activity, MGSA is a potent inflammatory agonist with neutrophil-stimulating properties.

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Year:  1990        PMID： 2185333      PMCID： PMC2187876          DOI： 10.1084/jem.171.5.1797

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  16 in total

1.  Novel neutrophil-stimulating peptides.

Authors:  J Westwick; S W Li; R D Camp
Journal:  Immunol Today       Date:  1989-05

2.  Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: biological equivalence between natural and recombinant neutrophil-activating factor.

Authors:  I Lindley; H Aschauer; J M Seifert; C Lam; W Brunowsky; E Kownatzki; M Thelen; P Peveri; B Dewald; V von Tscharner
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

3.  Role of disulfide bridges in determining the biological activity of interleukin 3.

Authors:  I Clark-Lewis; L E Hood; S B Kent
Journal:  Proc Natl Acad Sci U S A       Date:  1988-11       Impact factor: 11.205

4.  Functional diversity of gro gene expression in human fibroblasts and mammary epithelial cells.

Authors:  A Anisowicz; D Zajchowski; G Stenman; R Sager
Journal:  Proc Natl Acad Sci U S A       Date:  1988-12       Impact factor: 11.205

5.  Purification and partial biologic characterization of a human lymphocyte-derived peptide with potent neutrophil-stimulating activity.

Authors:  J M Schröder; U Mrowietz; E Christophers
Journal:  J Immunol       Date:  1988-05-15       Impact factor: 5.422

6.  Chemiluminescence detection of H2O2 produced by human neutrophils during the respiratory burst.

Authors:  M P Wymann; V von Tscharner; D A Deranleau; M Baggiolini
Journal:  Anal Biochem       Date:  1987-09       Impact factor: 3.365

7.  Structure-function studies of human granulocyte-macrophage colony-stimulating factor. Identification of residues required for activity.

Authors:  I Clark-Lewis; A F Lopez; L B To; M A Vadas; J W Schrader; L E Hood; S B Kent
Journal:  J Immunol       Date:  1988-08-01       Impact factor: 5.422

8.  In vivo inflammatory activity of neutrophil-activating factor, a novel chemotactic peptide derived from human monocytes.

Authors:  I Colditz; R Zwahlen; B Dewald; M Baggiolini
Journal:  Am J Pathol       Date:  1989-04       Impact factor: 4.307

9.  Expression and secretion of gro/MGSA by stimulated human endothelial cells.

Authors:  D Z Wen; A Rowland; R Derynck
Journal:  EMBO J       Date:  1989-06       Impact factor: 11.598

10.  Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin.

Authors:  A Richmond; E Balentien; H G Thomas; G Flaggs; D E Barton; J Spiess; R Bordoni; U Francke; R Derynck
Journal:  EMBO J       Date:  1988-07       Impact factor: 11.598
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  90 in total

1.  Chemokines and atherosclerosis: what Adam Smith has to say about vascular disease.

Authors:  B J Rollins
Journal:  J Clin Invest       Date:  2001-11       Impact factor: 14.808

2.  Different functions for the interleukin 8 receptors (IL-8R) of human neutrophil leukocytes: NADPH oxidase and phospholipase D are activated through IL-8R1 but not IL-8R2.

Authors:  S A Jones; M Wolf; S Qin; C R Mackay; M Baggiolini
Journal:  Proc Natl Acad Sci U S A       Date:  1996-06-25       Impact factor: 11.205

Review 3.  Chemokine Regulation of Neutrophil Infiltration of Skin Wounds.

Authors:  Yingjun Su; Ann Richmond
Journal:  Adv Wound Care (New Rochelle)       Date:  2015-11-01       Impact factor: 4.730

4.  SpyA, a C3-like ADP-ribosyltransferase, contributes to virulence in a mouse subcutaneous model of Streptococcus pyogenes infection.

Authors:  Jessica S Hoff; Mark DeWald; Steve L Moseley; Carleen M Collins; Jovanka M Voyich
Journal:  Infect Immun       Date:  2011-03-21       Impact factor: 3.441

5.  A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury.

Authors:  Jiurong Liang; Yoosun Jung; Robert M Tighe; Ting Xie; Ningshan Liu; Maura Leonard; Michael Dee Gunn; Dianhua Jiang; Paul W Noble
Journal:  Am J Physiol Lung Cell Mol Physiol       Date:  2012-01-27       Impact factor: 5.464

6.  Detrimental Influence of Alveolar Macrophages on Protective Humoral Immunity during Francisella tularensis SchuS4 Pulmonary Infection.

Authors:  Donald J Steiner; Yoichi Furuya; Dennis W Metzger
Journal:  Infect Immun       Date:  2018-03-22       Impact factor: 3.441

7.  Formation of neutrophil-activating peptide 2 from platelet-derived connective-tissue-activating peptide III by different tissue proteinases.

Authors:  B D Car; M Baggiolini; A Walz
Journal:  Biochem J       Date:  1991-05-01       Impact factor: 3.857

8.  HMGI(Y) and Sp1 in addition to NF-kappa B regulate transcription of the MGSA/GRO alpha gene.

Authors:  L D Wood; A A Farmer; A Richmond
Journal:  Nucleic Acids Res       Date:  1995-10-25       Impact factor: 16.971

9.  [Primary nasal epithelial cells and fibroblasts have inflammation-inducing functions].

Authors:  C Rudack; W Stoll; W Hermann
Journal:  HNO       Date:  2003-04-08       Impact factor: 1.284

10.  Removal of a 3' non-coding sequence is an initial step in degradation of gro alpha mRNA and is regulated by interleukin-1.

Authors:  M Y Stoeckle
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971
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