OBJECTIVES: The UK National Health Service Bowel Cancer Screening Programme (BCSP) is based on a strategy of biennial faecal occult blood (FOB) testing. Positive results are classified as 'abnormal' or 'weak positive' based on the number of positive windows per kit or need for repeat testing. Colonoscopy is offered to both groups. We evaluate the relationship between FOB test positivity and clinical outcome in the BCSP. SETTING: The South of Tyne and Tees (UK) Bowel Cancer Screening Centres. METHODS: Data were collected prospectively on all individuals who were offered FOB testing and colonoscopy between February 2007 and February 2009. Univariable and multivariable analyses were performed to investigate the relationship between FOB test positivity and clinical outcome. RESULTS: Following FOB testing, 1524 individuals underwent colonoscopy, 1259 (83%) after a 'weak positive' and 265 (17%) an 'abnormal' result. Cancer was detected in 180 (11.8%) and adenomas in 758 (49.7%). Individuals with an 'abnormal' result were more likely to have cancer or be 'high risk' for the development of future adenomas (110/265, 41.5%) than those with 'weak positive' results, (236/1259, 18.7%, P < 0.0001). Those with Dukes stage B, C or D cancers or cancers proximal to the splenic flexure were more likely to have an 'abnormal' result. CONCLUSIONS: The majority of colonoscopies were performed following 'weak positive' FOB results. Those with an 'abnormal' result were more likely to be diagnosed with cancer. The high yield of pathology in both the 'abnormal' and 'weak positive' groups justifies the need for colonoscopy in both.
OBJECTIVES: The UK National Health Service Bowel Cancer Screening Programme (BCSP) is based on a strategy of biennial faecal occult blood (FOB) testing. Positive results are classified as 'abnormal' or 'weak positive' based on the number of positive windows per kit or need for repeat testing. Colonoscopy is offered to both groups. We evaluate the relationship between FOB test positivity and clinical outcome in the BCSP. SETTING: The South of Tyne and Tees (UK) Bowel Cancer Screening Centres. METHODS: Data were collected prospectively on all individuals who were offered FOB testing and colonoscopy between February 2007 and February 2009. Univariable and multivariable analyses were performed to investigate the relationship between FOB test positivity and clinical outcome. RESULTS: Following FOB testing, 1524 individuals underwent colonoscopy, 1259 (83%) after a 'weak positive' and 265 (17%) an 'abnormal' result. Cancer was detected in 180 (11.8%) and adenomas in 758 (49.7%). Individuals with an 'abnormal' result were more likely to have cancer or be 'high risk' for the development of future adenomas (110/265, 41.5%) than those with 'weak positive' results, (236/1259, 18.7%, P < 0.0001). Those with Dukes stage B, C or D cancers or cancers proximal to the splenic flexure were more likely to have an 'abnormal' result. CONCLUSIONS: The majority of colonoscopies were performed following 'weak positive' FOB results. Those with an 'abnormal' result were more likely to be diagnosed with cancer. The high yield of pathology in both the 'abnormal' and 'weak positive' groups justifies the need for colonoscopy in both.
Authors: Richard F A Logan; Julietta Patnick; Claire Nickerson; Lynn Coleman; Matt D Rutter; Christian von Wagner Journal: Gut Date: 2011-12-07 Impact factor: 23.059
Authors: G Libby; D H Brewster; P L McClements; F A Carey; R J Black; J Birrell; C G Fraser; R J C Steele Journal: Br J Cancer Date: 2012-06-26 Impact factor: 7.640
Authors: J Geraghty; P Butler; H Seaman; J Snowball; S Sarkar; R Blanks; S Halloran; K Bodger; C J Rees Journal: Br J Cancer Date: 2014-09-16 Impact factor: 7.640
Authors: Ni Ni Moe Myint; Ajay M Verma; Daniel Fernandez-Garcia; Panchali Sarmah; Patrick S Tarpey; Saif Sattar Al-Aqbi; Hong Cai; Ricky Trigg; Kevin West; Lynne M Howells; Anne Thomas; Karen Brown; David S Guttery; Baljit Singh; Howard J Pringle; Ultan McDermott; Jacqui A Shaw; Alessandro Rufini Journal: Cell Death Dis Date: 2018-08-30 Impact factor: 8.469