BACKGROUND: Little is known about the aetiology of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME); prospective studies suggest a role for premorbid mood disorder. AIMS: To examine childhood and early adult adversity, ill health and physical activity as premorbid risk markers for CFS/ME by 42 years, taking psychopathology into account. METHOD: Data were from the 1958 British birth cohort, a prospective study from birth to 42 years (n = 11 419). The outcomes were self-reported CFS/ME (n = 127) and operationally defined CFS-like illness (n = 241) at 42 years. RESULTS: Adjusting for psychopathology, parental physical abuse (odds ratio (OR) = 2.10, 95% CI 1.16-3.81), childhood gastrointestinal symptoms (OR = 1.58, 95% CI 1.00-2.50) and parental reports of many colds (OR = 1.65, 95% CI 1.09-2.50) were independently associated with self-reported CFS/ME. Female gender and premorbid psychopathology were the only risk markers for CFS-like illness, independent of comorbid psychopathology. CONCLUSIONS: This confirms the importance of premorbid psychopathology in the aetiological pathways of CFS/ME, and replicates retrospective findings that childhood adversity may play a role in a minority.
BACKGROUND: Little is known about the aetiology of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME); prospective studies suggest a role for premorbid mood disorder. AIMS: To examine childhood and early adult adversity, ill health and physical activity as premorbid risk markers for CFS/ME by 42 years, taking psychopathology into account. METHOD: Data were from the 1958 British birth cohort, a prospective study from birth to 42 years (n = 11 419). The outcomes were self-reported CFS/ME (n = 127) and operationally defined CFS-like illness (n = 241) at 42 years. RESULTS: Adjusting for psychopathology, parental physical abuse (odds ratio (OR) = 2.10, 95% CI 1.16-3.81), childhood gastrointestinal symptoms (OR = 1.58, 95% CI 1.00-2.50) and parental reports of many colds (OR = 1.65, 95% CI 1.09-2.50) were independently associated with self-reported CFS/ME. Female gender and premorbid psychopathology were the only risk markers for CFS-like illness, independent of comorbid psychopathology. CONCLUSIONS: This confirms the importance of premorbid psychopathology in the aetiological pathways of CFS/ME, and replicates retrospective findings that childhood adversity may play a role in a minority.
Authors: J McBeth; B Tomenson; C A Chew-Graham; G J Macfarlane; J Jackson; A Littlewood; F H Creed Journal: J Psychosom Res Date: 2015-10-19 Impact factor: 3.006
Authors: Alice Russell; Nilay Hepgul; Naghmeh Nikkheslat; Alessandra Borsini; Zuzanna Zajkowska; Natalie Moll; Daniel Forton; Kosh Agarwal; Trudie Chalder; Valeria Mondelli; Matthew Hotopf; Anthony Cleare; Gabrielle Murphy; Graham Foster; Terry Wong; Gregor A Schütze; Markus J Schwarz; Neil Harrison; Patricia A Zunszain; Carmine M Pariante Journal: Psychoneuroendocrinology Date: 2018-12-17 Impact factor: 4.905
Authors: Jiyoung Song; Clara Johnson; Michael K Suvak; Norman Shields; Jeanine E M Lane; Candice M Monson; Shannon Wiltsey-Stirman Journal: Eur J Psychotraumatol Date: 2020-09-15