Literature DB >> 21852129

Identification of 5,6-substituted 4-aminothieno[2,3-d]pyrimidines as LIMK1 inhibitors.

Brad E Sleebs1, George Nikolakopoulos, Ian P Street, Hendrik Falk, Jonathan B Baell.   

Abstract

4-Aminobenzothieno[3,2-d]pyrimidines were previously identified in a high throughput screening campaign as LIMK1 inhibitors. Scaffold reversal led to the identification of a series of simple 5,6-substituted 4-aminothieno[2,3-d]pyrimidines with low micromolar inhibition of LIMK1.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21852129     DOI： 10.1016/j.bmcl.2011.07.050

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma.

Authors:  Bryce A Harrison; Zheng Y Almstead; Hugh Burgoon; Michael Gardyan; Nicole C Goodwin; Jason Healy; Ying Liu; Ross Mabon; Brett Marinelli; Lakshman Samala; Yulian Zhang; Terry R Stouch; N Andrew Whitlock; Suma Gopinathan; Beth McKnight; Shuli Wang; Nita Patel; Alan G E Wilson; Brian D Hamman; Dennis S Rice; David B Rawlins
Journal:  ACS Med Chem Lett       Date:  2014-11-24       Impact factor: 4.345

2.  Bis-aryl urea derivatives as potent and selective LIM kinase (Limk) inhibitors.

Authors:  Yan Yin; Ke Zheng; Nibal Eid; Shannon Howard; Ji-Hak Jeong; Fei Yi; Jia Guo; Chul Min Park; Mathieu Bibian; Weilin Wu; Pamela Hernandez; HaJeung Park; Yuntao Wu; Jun-Li Luo; Philip V LoGrasso; Yangbo Feng
Journal:  J Med Chem       Date:  2015-02-04       Impact factor: 7.446

Review 3.  LIM Kinases, Promising but Reluctant Therapeutic Targets: Chemistry and Preclinical Validation In Vivo.

Authors:  Rayan Berabez; Sylvain Routier; Hélène Bénédetti; Karen Plé; Béatrice Vallée
Journal:  Cells       Date:  2022-06-30       Impact factor: 7.666

Review 4.  LIM kinases: cofilin and beyond.

Authors:  Chloé Prunier; Renaud Prudent; Reuben Kapur; Karin Sadoul; Laurence Lafanechère
Journal:  Oncotarget       Date:  2017-06-20

5.  Damnacanthal, an effective inhibitor of LIM-kinase, inhibits cell migration and invasion.

Authors:  Kazumasa Ohashi; Kaori Sampei; Mami Nakagawa; Naoto Uchiumi; Tatsuya Amanuma; Setsuya Aiba; Masato Oikawa; Kensaku Mizuno
Journal:  Mol Biol Cell       Date:  2014-01-29       Impact factor: 4.138

6.  Synthesis of Some 4,5-Dihydrothieno[3,2-e][1,2,4]Triazolo[4,3-a] Pyrimi-dine-2-Carboxamides as Anti-Inflammatory and Analgesic Agents.

Authors:  Omaima G Shaaban; Ola H Rizk; Aida E Bayad; Ibrahim M El-Ashmawy
Journal:  Open Med Chem J       Date:  2013-11-29
  6 in total

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