Literature DB >> 21851818

Wnt/Myc interactions in intestinal cancer: partners in crime.

Kevin Myant1, Owen J Sansom.   

Abstract

Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis. Copyright Â
© 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21851818     DOI： 10.1016/j.yexcr.2011.08.001

Source DB:  PubMed          Journal:  Exp Cell Res        ISSN： 0014-4827            Impact factor:   3.905


  23 in total

1.  Rictor regulates FBXW7-dependent c-Myc and cyclin E degradation in colorectal cancer cells.

Authors:  Zheng Guo; Yuning Zhou; B Mark Evers; Qingding Wang
Journal:  Biochem Biophys Res Commun       Date:  2012-01-20       Impact factor: 3.575

2.  Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.

Authors:  Krishnakali Dasgupta; Jong Uk Chung; Kesava Asam; Juhee Jeong
Journal:  Dev Biol       Date:  2019-07-24       Impact factor: 3.582

3.  Deptor Is a Novel Target of Wnt/β-Catenin/c-Myc and Contributes to Colorectal Cancer Cell Growth.

Authors:  Qingding Wang; Yuning Zhou; Piotr Rychahou; Jennifer W Harris; Yekaterina Y Zaytseva; Jinpeng Liu; Chi Wang; Heidi L Weiss; Chunming Liu; Eun Y Lee; B Mark Evers
Journal:  Cancer Res       Date:  2018-04-17       Impact factor: 12.701

4.  Mouse organoids as an in vitro tool to study the in vivo intestinal response to cytotoxicants.

Authors:  F Jardi; C Kelly; C Teague; H Fowler-Williams; D C Sevin; D Rodrigues; H Jo; S Ferreira; B Herpers; M Van Heerden; T de Kok; C Pin; A Lynch; C A Duckworth; S De Jonghe; L Lammens; D M Pritchard
Journal:  Arch Toxicol       Date:  2022-10-06       Impact factor: 6.168

5.  The Wnt/β-catenin/T-cell factor 4 pathway up-regulates high-mobility group A1 expression in colon cancer.

Authors:  Bethany M Bush; Ashton T Brock; Jiayue A Deng; Ronald A Nelson; Takita Felder Sumter
Journal:  Cell Biochem Funct       Date:  2012-09-07       Impact factor: 3.685

Review 6.  Drosophila Myc: A master regulator of cellular performance.

Authors:  Daniela Grifoni; Paola Bellosta
Journal:  Biochim Biophys Acta       Date:  2014-07-08

7.  PI3K-dependent GSK3ß(Ser9)-phosphorylation is implicated in the intestinal epithelial cell wound-healing response.

Authors:  Thomas Karrasch; Tanja Spaeth; Brigitte Allard; Christian Jobin
Journal:  PLoS One       Date:  2011-10-19       Impact factor: 3.240

8.  Regulated Expression of Chromobox Homolog 5 Revealed in Tumors of Apc(Min) (/+) ROSA11 Gene Trap Mice.

Authors:  Andrew T Thliveris; Linda Clipson; Lacy L Sommer; Barry A Schoenike; Jason R Hasenstein; Cassandra L Schlamp; Caroline M Alexander; Michael A Newton; William F Dove; James M Amos-Landgraf
Journal:  G3 (Bethesda)       Date:  2012-05-01       Impact factor: 3.154

9.  Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis.

Authors:  Babita Madan; Nathan Harmston; Gahyathiri Nallan; Alex Montoya; Peter Faull; Enrico Petretto; David M Virshup
Journal:  J Clin Invest       Date:  2018-11-12       Impact factor: 14.808

10.  MiR-590-5P inhibits growth of HepG2 cells via decrease of S100A10 expression and Inhibition of the Wnt pathway.

Authors:  Xiangxiang Shan; Yufeng Miao; Rengen Fan; Haixin Qian; Ping Chen; Hongqi Liu; Xiaomei Yan; Jianping Li; Fen Zhou
Journal:  Int J Mol Sci       Date:  2013-04-18       Impact factor: 5.923
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