OBJECTIVE: • To determine the incidence and significance of lymph nodes in the anterior prostatovesicular lymphofatty tissue. PATIENTS AND METHODS: • One hundred and twenty patients with clinically localized prostate cancer underwent robot-assisted laparoscopic radical prostatectomy with excision of anterior prostatovesicular tissue at a single institution over a 6-month period. • Tissue was sent for pathological analysis. • Separate pelvic lymph node dissection was carried out in moderate-risk and high-risk patients. RESULTS: • A total of 20 out of 120 patients (16.7%) had lymph nodes in the anterior lymphofatty tissue. • Average lymph node number when present was 1.5 (one to three). • Pathological assessment of the lymph nodes revealed metastatic prostate cancer in 3 out of 120 (2.5%) patients, each of whom had adverse pathological features. • Patients with metastatic lymph nodes in the anterior tissue did not have cancer involvement of the pelvic lymph nodes. • Patients with lymph nodes found in the anterior lymphofatty tissue were slightly younger but were otherwise similar with respect to other demographics, prostate-specific antigen, biopsy Gleason score, clinical stage, pathological stage, pathological Gleason score, seminal vesicle invasion, and margin status. CONCLUSIONS: • Anterior lymphofatty tissue overlying the prostate occasionally contains lymph nodes that can harbour malignant disease and routine excision may eradicate regional tumour burden. • Of patients with nodes, 15% were found to have malignant involvement. • The long-term impact on progression-free and overall survival requires further study.
OBJECTIVE: • To determine the incidence and significance of lymph nodes in the anterior prostatovesicular lymphofatty tissue. PATIENTS AND METHODS: • One hundred and twenty patients with clinically localized prostate cancer underwent robot-assisted laparoscopic radical prostatectomy with excision of anterior prostatovesicular tissue at a single institution over a 6-month period. • Tissue was sent for pathological analysis. • Separate pelvic lymph node dissection was carried out in moderate-risk and high-risk patients. RESULTS: • A total of 20 out of 120 patients (16.7%) had lymph nodes in the anterior lymphofatty tissue. • Average lymph node number when present was 1.5 (one to three). • Pathological assessment of the lymph nodes revealed metastatic prostate cancer in 3 out of 120 (2.5%) patients, each of whom had adverse pathological features. • Patients with metastatic lymph nodes in the anterior tissue did not have cancer involvement of the pelvic lymph nodes. • Patients with lymph nodes found in the anterior lymphofatty tissue were slightly younger but were otherwise similar with respect to other demographics, prostate-specific antigen, biopsy Gleason score, clinical stage, pathological stage, pathological Gleason score, seminal vesicle invasion, and margin status. CONCLUSIONS: • Anterior lymphofatty tissue overlying the prostate occasionally contains lymph nodes that can harbour malignant disease and routine excision may eradicate regional tumour burden. • Of patients with nodes, 15% were found to have malignant involvement. • The long-term impact on progression-free and overall survival requires further study.
Authors: Nilda González-Roibón; Jeong S Han; Stephen Lee; Zhaoyong Feng; Sehbal Arslankoz; Nathaniel Smith; Philip M Pierorazio; Elizabeth Humphreys; Theodore L Deweese; Alan W Partin; Trinity J Bivalacqua; Misop Han; Bruce Trock; Georges J Netto Journal: Int J Surg Pathol Date: 2013-04-05 Impact factor: 1.271
Authors: Young Suk Kwon; Yun-Sok Ha; Parth K Modi; Amirali Salmasi; Jaspreet S Parihar; Neal Patel; Izak Faiena; Michael May; David I Lee; Elton Llukani; Tuliao Patrick; Koon Ho Rha; Thomas Ahlering; Douglas Skarecky; Hanjong Ahn; Seung-Kwon Choi; Sejun Park; Seong Soo Jeon; Yen-Chuan Ou; Daniel Eun; Varsha Manucha; David Albala; Ketan Badani; Bertram Yuh; Nora Ruel; Tae-Hwan Kim; Tae Gyun Kwon; Daniel Marchalik; Jonathan Hwang; Wun-Jae Kim; Isaac Yi Kim Journal: BMC Urol Date: 2015-08-01 Impact factor: 2.264